Results 71 to 80 of about 2,892,641 (307)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Hierarchical Action Control: Adaptive Collaboration Between Actions and Habits
Frontiers in Psychology, 2019 It is now commonly accepted that instrumental actions can reflect goal-directed control; i.e., they can show sensitivity to changes in the relationship to and the value of their consequences.
Bernard W. Balleine, Amir Dezfouli
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Targeting Human Model-Free Processing
, 2020 Examining the effect of early rewards on model-free decision ...
Diego Garaialde
core +1 more source
Model-Free Coordinated Control for MHTGR-Based Nuclear Steam Supply Systems
Energies, 2016 The modular high temperature gas-cooled reactor (MHTGR) is a typical small modular reactor (SMR) that offers simpler, standardized and safer modular design by being factory built, requiring smaller initial capital investment, and having a shorter ...
Zhe Dong
doaj +1 more source
MM-KTD: Multiple Model Kalman Temporal Differences for Reinforcement Learning
IEEE Access, 2020 Background: There has been an increasing surge of interest on development of advanced Reinforcement Learning (RL) systems as intelligent approaches to learn optimal control policies directly from smart agents' interactions with the environment ...
Parvin Malekzadeh +4 more
doaj +1 more source
SSRN Electronic Journal, 2013 We consider Constant Proportion Portfolio Insurance (CPPI) and its dynamic extension, which may be called Dynamic Proportion Portfolio Insurance (DPPI). It is shown that these investment strategies work within the setting of Föllmer's pathwise Itô calculus, which makes no probabilistic assumptions whatsoever.
openaire +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source