Results 71 to 80 of about 8,982 (215)

Cross-Coupled Conditional Funnel Control: A Model-Free Approach for Load-Following Operation of Pressurized Heavy Water Reactor

Eng
This study presents the design of a model-free control scheme for the load-following operation of a Pressurized Heavy Water Reactor (PHWR), which is a 70th-order Multi-Input Multi-Output, strongly coupled and open-loop unstable energy-generating system ...
Fahad Wallam, Attaullah Y. Memon
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

On the control of robot manipulator: A model-free approach

Journal of Computational Science, 2019
The works presented in this paper deal with the control of a highly nonlinear and uncertain system using the new setting of "Model-Free Control" and its related intelligent Proportional, Integral and Derivative (iPID) regulators. Such approach that can be designed, using only the input and output data of the controlled device and the new algebraic ...
Abouaïssa, Hassane, Chouraqui, Samira
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Traffic Signal Control via Reinforcement Learning: A Review on Applications and Innovations

Infrastructures
Traffic signal control plays a pivotal role in intelligent transportation systems, directly affecting urban mobility, congestion mitigation, and environmental sustainability.
Panagiotis Michailidis, Iakovos Michailidis, Charalampos Rafail Lazaridis, Elias Kosmatopoulos   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Model-Free Predictive Control for Improved Performance and Robustness of Three-Phase Quasi Z-Source Inverters

IEEE Access
This paper suggests a novel Model-Free Predictive Control (MFPC) approach for three-phase quasi Z-source inverters (qZSI). While Model Predictive Control (MPC) is popular for qZSI due to its ease of use and performance, it suffers from sensitivity to ...
Abderahmane Abid, Abualkasim Bakeer, Hani Albalawi, Mansour Bouzidi, Abderezak Lashab, Andrii Chub, Sherif A. Zaid   +6 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source