Results 81 to 90 of about 6,421,352 (290)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Control Regularization for Reduced Variance Reinforcement Learning [PDF]

, 2019
Dealing with high variance is a significant challenge in model-free reinforcement learning (RL). Existing methods are unreliable, exhibiting high variance in performance from run to run using different initializations/seeds.
Burdick, Joel W., Chaudhuri, Swarat, Cheng, Richard, Orosz, Gabor, Verma, Abhinav, Yue, Yisong   +5 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Some remarks on wheeled autonomous vehicles and the evolution of their control design

, 2016
Recent investigations on the longitudinal and lateral control of wheeled autonomous vehicles are reported. Flatness-based techniques are first introduced via a simplified model.
d'Andréa-Novel, Brigitte, Fliess, Michel, Menhour, Lghani, Mounier, Hugues   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Model-free control for machine tools

, 2020
Peer ...
Villagrá, Jorge, Join, Cédric, Haber Guerra, Rodolfo E., Fliess, Michel   +3 more
openaire   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

FS-DDPG: Optimal Control of a Fan Coil Unit System Based on Safe Reinforcement Learning

Buildings
To optimize the control of fan coil unit (FCU) systems under model-free conditions, researchers have integrated reinforcement learning (RL) into the control processes of system pumps and fans.
Chenyang Li, Qiming Fu, Jianping Chen, You Lu, Yunzhe Wang, Hongjie Wu   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Model-Free Speed Control for Pumping Kite Generator Systems Based on Nonlinear Hyperbolic Tangent Tracking Differentiator

Applied Sciences
This paper investigates the emerging field of grid-connected wind-powered pumping kite generator system (PKGS), focusing on the challenges associated with the generator/motor speed control. Conventional use of proportional–integral (PI) controllers faces
Mouaad Belguedri, Abdeldjabar Benrabah, Farid Khoucha, Emmanuel Delaleau, Mohamed Benbouzid, Khelifa Benmansour   +5 more
doaj   +1 more source