Results 111 to 120 of about 25,040,689 (239)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
International Journal of Electrical Power & Energy SystemsModel predictive current control (MPCC) for permanent magnet synchronous motors (PMSMs) relies heavily on the accuracy of the system model and parameters.
Ge Liang +4 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Model predictive control for gust load alleviation
, 2012 For economical and ecological reasons aircraft are required to become more efficient by reducing fuel consumption and CO2 emissions. One way to achieve these objectives is to decrease the weight of the aircraft structure.
Giesseler, Hans Gerd +4 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
A data driven model-free predictive current control for grid-connected inverters
电力工程技术Traditional model predictive current control has been widely studied in the field of grid-connected inverter control due to its rapid response and multi-objective optimization capabilities.
Jindong YANG +3 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Robust predictive feedback control for constrained systems [PDF]
, 2004 A new method for the design of predictive controllers for SISO systems is presented. The proposed technique allows uncertainties and constraints to be concluded in the design of the control law. The goal is to design, at each sample instant, a predictive
Giovanini, Leonardo, Grimble, Michael
core
Improved non‐cascaded continuous‐set model‐free predictive control scheme for PMSM drives
IET Power ElectronicsThis article presents an improved multiple‐step model‐free predictive control (MS‐MFPC) method for permanent magnet synchronous motor (PMSM) drives. Specifically, a reduced‐order MS‐MFPC based on an ultra‐local model, which employs only the input and ...
Bowen Xu +4 more
doaj +1 more source