Results 201 to 210 of about 11,068 (304)

Liraglutide combined with dapagliflozin treatment improves myocardial disease and endothelial dysfunction in T2DM mice

Journal of Diabetes Investigation, EarlyView.
Liraglutide combined with Dapagliflozin treatment improves myocardial disease and endothelial dysfunction in T2DM mice. Diabetic cardiomyopathy (DCM) and endothelial dysfunction were established in mice via HFD and STZ injection. The combination therapy of Liraglutide and Dapagliflozin synergistically improved metabolic parameters and attenuated ...
An‐Jun Tan, Tian‐Rong Li, Jing‐Jing Yang, Xiao‐Lu Li, Wen‐Qin Li, Jin‐Wen Yu   +5 more
wiley   +1 more source

SMR Peptide Modulates Tumor-Derived Extracellular Vesicles microRNA and Inflammatory Transcript Signatures in TNBC. [PDF]

Cells
Huang MB, Yan F, Jadoon U, Wu JY, Brena D, Johnson EL, Stiles J, Yang L, Rivers BM, Bond VC.   +9 more
europepmc   +1 more source

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, EarlyView.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

A tri-specific EGFR/cMet/VEGF antibody demonstrates potent multi-mechanistic activity in preclinical triple-negative breast cancer models. [PDF]

J Biol Chem
Pu P, Jin Y, Zhang S, Xu Y, Chen P, Zhou F, Sun P, Jiang H, Huang S, Chen L, Fu M, Zha Z, MacWilliams MP, Chiu ML.   +13 more
europepmc   +1 more source

Melatonin seed priming: A climate‐smart, green strategy to enhance abiotic stress tolerance in plants

Journal of Integrative Plant Biology, EarlyView.
This review synthesizes how melatonin seed priming preconditions seeds to enhance tolerance against diverse abiotic stresses. It highlights the underlying mechanisms and proposes an integrative roadmap of advanced molecular and breeding tools to design next‐generation, stress‐smart plants.
Ali Raza, Yiran Li, Chunli Guo, Erna Karalija, Evgenios Agathokleous, Meng Jiang, Jie Zhou, Vasileios Fotopoulos, Zhangli Hu   +8 more
wiley   +1 more source

An Intelligent Magneto-Mechanical Platform for Cellular Sensing in 3D Microenvironments. [PDF]

Adv Sci (Weinh)
Quan Y, Wang Y, Ding S, Zhou B, Zhou Y.
europepmc   +1 more source

A cytochrome P450 gene, GmSUR2a, confers submergence tolerance and improves yield in soybean by modulating auxin homeostasis

Journal of Integrative Plant Biology, EarlyView.
The key cytochrome P450 gene GmSUR2a enables soybeans to withstand destructive submergence stress. By lowering the level of the plant hormone indole‐3‐acetic acid, this gene improves soybean survival and increases field yield. It offers an important tool for breeding stress‑resilient soybeans, securing food production against extreme weather conditions.
Yangyang Chen, Pingzhang Feng, Mengwei Zheng, Lipei Zhao, Yi Li, Yali Jing, Yisa Wang, Bo Zhang, Changzhong Liu, Chengyu Wei, Jijun Yan, Jinfang Chu, Shanshan Chu, Erhui Xiong, Yongqing Jiao   +14 more
wiley   +1 more source

A novel explainable AI for revealing determinants of cancer drug response through integrative multi-omics analysis. [PDF]

Front Oncol
Gopalan SP, Sundararajan V.
europepmc   +1 more source

An Empirical Investigation of the Utility of ‘pre-CIM’ models

that, by allowing a variety of stakeholders to take part in modelling, projects will be both more efficient than traditional approaches and will produce software that meets the needs of those stakeholders. This will be facilitated by transforming initial
Phalp, Keith T., Jeary, Sherry
core  

First Tetraploa Genome and Multi‐Omics Analysis Reveal Key Plant‐Microbe‐Soil Interactions for Salt Tolerance and Yield Improvement of Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Salinity is a major threat to global agricultural productivity of staple crops such as wheat. Although microbial‐based solutions hold promise for alleviating salinity stress, practical implementation is hindered by insufficient mechanistic characterization of bioinoculants and their interactions with plants.
Cheng‐Wei Qiu, Shuo Zhang, Zi‐Feng Gao, Zhong‐Hua Chen, Chulong Zhang, Mohamed Abdelalim Ali, Feibo Wu   +6 more
wiley   +1 more source