Results 211 to 220 of about 9,597 (251)

Evidence That the Protein Phosphatase Activity of PTEN Contributes to Embryonic Development and Tumor Suppression

Cancer Science, EarlyView.
Mice expressing only mutant PTEN Y138L, a protein which shows normal suppression of cellular AKT yet lacks protein phosphatase activity, die in utero, and heterozygous mice display a range of tumors. This indicates both the lipid and protein phosphatase activities of PTEN work together for normal tumor suppression and embryonic development.
Priyanka Tibarewal, Laura Spinelli, Nisha Kriplani, Helen Wise, Nadege Poncet, Giulia Marzano, Karen E. Anderson, Katarzyna M. Grzes, Zofia Varyova, Mahreen Adil, C. Peter Downes, Phillip T. Hawkins, Len R. Stephens, Kate G. Storey, Doreen A. Cantrell, Bart Vanhaesebroeck, Nicholas R. Leslie   +16 more
wiley   +1 more source

MODULATING OXIDATIVE STRESS AND INFLAMMATION: SODIUM BUTYRATE'S THERAPEUTIC PROMISE IN EXPERIMENTAL COLITIS. [PDF]

Arq Gastroenterol
Murshed NMF, Swaroopa S, Al-Awadhi SSA, Poonacha SK, D'Souza C, Hosapatna Laxminarayana KP.   +5 more
europepmc   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Secukinumab Mitigates Cisplatin-Induced Nephrotoxicity and Enhances Cisplatin Cytotoxicity in MCF-7 Cells via IL-17A/NF-κB Axis Modulation. [PDF]

Toxics
Alenezi FN, Zaghloul MS, Nader MA, Abdelmageed ME.   +3 more
europepmc   +1 more source

Model-Driven Architecture with Emphasis on Industrial Applications : 1st European Workshop, MDA-IA 2004, Enschede, the Netherlands, March 17-18 2004, Proceedings

, 2004
van Sinderen, Marten J., Ferreira Pires, Luis   +1 more
openaire   +1 more source

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MDA Redux: Practical Realization of Model Driven Architecture

Seventh International Conference on Composition-Based Software Systems (ICCBSS 2008), 2008
Models and model-based transformations are a key part of effective automated software development approaches. Unfortunately, early enthusiasm for Model Driven Architecture (MDA) has dissipated to the point that many people are openly skeptical of the value of any model-driven approach.
Alan W Brown
exaly   +2 more sources

An XML-based framework for bidirectional transformation in model-driven architecture (MDA)

Software Engineering Notes: an Informal Newsletter of the Special Interest Committee on Software Engineering / ACM, 2009
A model transformation in Model-Driven Architecture is the generation of a target model from a source model, which is normally based on different processes. These processes are described by a transformation definition, consisting of a number of transformation rules, and executed with the help of a transformational tool.
Shahid Nazir Bhatti
exaly   +2 more sources

Model Driven Architecture (MDA)

Advances in Computer and Electrical Engineering Book Series, 2010
The architecture of a system is a specification of software components, interrelationships, and rules for component interactions and evolution over time. In 2001 OMG, adopted an architecture standard, the Model Driven Architecture (MDA). MDA is an architectural framework for improving portability, interoperability and reusability through separation of ...
Liliana Maria Favre
exaly   +2 more sources

Exploring a model-driven architecture (MDA) approach to health care information systems development

International Journal of Medical Informatics, 2008
To explore the potential of the model-driven architecture (MDA) in health care information systems development.An MDA is conceptualized and developed for a health clinic system to track patient information. A prototype of the MDA is implemented using an advanced MDA tool. The UML provides the underlying modeling support in the form of the class diagram.
Wullianallur Raghupathi
exaly   +3 more sources

Introduction: Models, Modeling, and Model-Driven Architecture (MDA)

2005
Models, modeling, and Model-Driven Architecture (MDA) are the basis for a set of development approaches known as model-driven development (MDD). Models are used to reason about a problem domain and design a solution in the solution domain. Relationships between these models provide a web of dependencies that record the process by which a solution is ...
Alan W Brown
exaly   +2 more sources