Results 71 to 80 of about 11,068 (304)

Software representation methodology for agile application development: An architectural approach

Redes de Ingeniería, 2016
The generation of Web applications represents the execution of repetitive tasks, this process involves determining information structures, the generation of different types of components and finally deployment tasks and tuning applications.
Alejandro Paolo Daza Corredor, John Freddy Parra Peña, Lilia Marcela Espinosa Rodriguez   +2 more
doaj   +1 more source

Distribution pattern-driven development of service architectures [PDF]

, 2009
Distributed systems are being constructed by composing a number of discrete components. This practice is particularly prevalent within the Web service domain in the form of service process orchestration and choreography.
Barrett,Ronan, Pahl, Claus, Barrett, Ronan, Pahl,Claus   +3 more
core   +1 more source

Covalent Inhibition of SHMT2 by Gambogic Acid Induces Ferroptosis Through Mitochondrial Collapse in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In this study, chemoproteomics combined with genetic and functional analyses was integrated to identify SHMT2 as a covalent and functional target of gambogic acid (GA) in triple‐negative breast cancer (TNBC). Further validation demonstrated that GA selectively modifies the Cys241 site of SHMT2, triggering mitochondrial dysfunction, activating the Nrf2 ...
Tong Yang, Chong Qiu, Yulei Li, Ying Zhang, Chen Wang, Jie Zhou, Zheng Chu, Ang Ma, Ling Huang, Yin Kwan Wong, Junzhe Zhang, Peng Gao, Cui Liu, Junhua Zhang, Huan Tang, Jigang Wang   +15 more
wiley   +1 more source

A Model Driven Framework for Collaborative and Dynamic Design and Implementation of NoSQL-Oriented Data warehouses

Jordanian Journal of Computers and Information Technology
Nowadays, modernizing the data warehouse ecosystem is a key challenge in decision support systems. This modernization is crucial for ensuring scalability and meeting evolving business requirements, especially with the advent of big data.
Khadija Letrache, Mohammed Ramdani
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Model Oriented Approach for Industrial Software Development

Моделирование и анализ информационных систем, 2015
The article considers the specifics of a model oriented approach to software development based on the usage of Model Driven Architecture (MDA), Model Driven Software Development (MDSD) and Model Driven Development (MDD) technologies.
P. D. Drobintsev, V. P. Kotlyarov, N. V. Voinov, I. V. Nikiforov   +3 more
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Una visión a la propuesta de Arquitectura Dirigida por Modelos

Revista UNIMAR, 2016
Este documento presenta un acercamiento a la iniciática Model Driven Architecture (MDA, Arquitectura Dirigida por Modelos) propuesta por Object Management Group (OMG). MDA separa la lógica de la aplicación del negocio.
Luis Muñoz, Guillermo Solarte, Douglas Hernández Heredia   +2 more
doaj  

A Model-Driven Architecture Solution for Multi-Platform Mobile App Development

Tehnički Glasnik
This paper presents a comprehensive Model Driven Architecture (MDA) approach for multi-platform mobile app development. We introduce a UML-based metamodel that encapsulates essential mobile app elements, including views, controls, resources, and events ...
Ayoub Korchi, Mohamed Karim Khachouch, Younes Lakhrisi   +2 more
doaj   +1 more source

A MDA Approach for avigational and User Perspectives

CLEI Electronic Journal, 2011
The study presented in this paper focuses on a navigational and user perspectives analysis of Web applications, highlighting some of their critical points for modeling.
Magalí González, Jorge Casariego, Juan Josee Bareiro, Luca Cernuzzi, Oscar Pastor   +4 more
doaj   +1 more source