Results 111 to 120 of about 1,743,272 (302)

Towards the Model-Driven Engineering of Secure yet Safe Embedded Systems

open access: yes, 2014
We introduce SysML-Sec, a SysML-based Model-Driven Engineering environment aimed at fostering the collaboration between system designers and security experts at all methodological stages of the development of an embedded system.
Apvrille, Ludovic, Roudier, Yves
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

OCL and Model Driven Engineering [PDF]

open access: yes, 2005
Precise modeling is essential to the success of the OMG’s Model Driven Architecture initiative. At the modeling level (M1) OCL allows for the precision needed to write executable models. Can OCL be extended to become a full high-level executable language with side-effects?
Jean Bézivin   +8 more
openaire   +1 more source

A Contrast- and Luminance-Driven Multiscale Netowrk Model of Brightness Perception [PDF]

open access: yes, 1994
A neural network model of brightness perception is developed to account for a wide variety of data, including the classical phenomenon of Mach bands, low- and high-contrast missing fundamental, luminance staircases, and non-linear contrast effects ...
Mingolla, Ennio   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

CSIMQ Anniversary Editor-in-Chief Thoughts and Editorial Introduction to Issue 38: Model-based and Decision Support Methods for Next-generation Information Systems

open access: yesComplex Systems Informatics and Modeling Quarterly
The 38th issue of CSIMQ comprises four articles selected by guest issue editors on topics related to novel decision support methods or model-based frameworks for evolving or evaluating information systems.
Anders Flodström   +2 more
doaj   +1 more source

Model Driven Language Engineering

open access: yesElectronic Notes in Theoretical Computer Science, 2003
AbstractThere is currently much interest in model driven approaches to software engineering. The basic idea is to make business, architecture and design models frst class artefacts that are not discarded once the code gets built, but rather can be exercised independently, be reconciled with each other and underlying implementations, and used to ...
openaire   +1 more source

A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems [PDF]

open access: yes, 2017
Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products.
Domínguez-Mayo, F.J   +7 more
core  

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