Results 121 to 130 of about 1,743,272 (302)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Model-driven engineering city spaces via bidirectional model transformations. [PDF]
Softw Syst Model, 2021 Visconti E, Tsigkanos C, Hu Z, Ghezzi C.
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Industrial-strength Rule Interoperability using Model Driven Engineering [PDF]
, 2008 Model Driven Engineering (MDE) is rapidly maturing and is being deployed in several situations. We report here on an experiment conducted in the context of ILOG, a leader in the development of Business Rule Management Systems (BRMS).
Albert, Patrick +3 more
core +2 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Metamodel Instance Generation: A systematic literature review [PDF]
, 2012 Modelling and thus metamodelling have become increasingly important in Software Engineering through the use of Model Driven Engineering. In this paper we present a systematic literature review of instance generation techniques for metamodels, i.e.
Monahan, Rosemary +2 more
core +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Distributed embedded control systems design with verification support
Моделирование и анализ информационных систем, 2010 We consider a problem of integrating a formal method of verification (model checking) into the process of designing complex distributed software systems to improve the quality of software. We use an approach based on the Model-Driven Engineering.
I. V. Shoshmina
doaj
, 2014 One of the common problems of system development projects is that the system documentation is often outdated and does not describe the latest version of the system.
Mou, Dongyue +2 more
core