Results 51 to 60 of about 308,743 (257)

Gradient vs. Non-Gradient-Based Model Free Control Algorithms: Analysis and Applications to Nonlinear Systems

Applied Sciences
Against the background of the development of control systems, Data Driven Control (DDC) methods are becoming more and more popular, given the system’s independence from physical models and the possibility of quickly tuning the controller.
Andrei Baciu, Corneliu Lazar
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Safe Switching Model-Free Value Iteration for General Nonlinear Systems

IEEE Access
This paper presents a solution to the well-known challenge of ensuring safety guarantees during the evaluation of controllers tuned using Value Iteration (VI) techniques on real systems.
Timotei Lala
doaj   +1 more source

Model-Free Adaptive Control of pH Value of Wet Desulfurization Slurry under Switching of Multiple Working Conditions

Complexity, 2020
In limestone-gypsum wet flue gas desulfurization process, the change process of pH value of slurry in absorption tower is a typical nonlinear system with time delay and various uncertainties, so it is difficult to establish an accurate mathematical model
Jian Liu, Xiaoli Li, Jihan Li, Kang Wang, Fuqiang Wang, Guimei Cui   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A model-free fuzzy adaptive trajectory tracking control algorithm based on dynamic surface control

International Journal of Advanced Robotic Systems, 2020
According to the robot’s dynamics, a high performance algorithm based on dynamic surface control is introduced to track desired trajectory, and simulations are conducted on a selective compliance assembly robot arm-type manipulator to verify the ...
Mingsi Tong, Weiyang Lin, Xiang Huo, Zishu Jin, Chengzong Miao   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Compact Model-Free Adaptive Control Algorithm for Discrete-Time Nonlinear Systems

IEEE Access, 2019
In model free adaptive control (MFAC), a virtual equivalent dynamic linearized model is built. The linearization length constants (LLCs) of the virtual equivalent dynamic linearized model are selected by the practitioner based on experience.
Xiaofei Zhang, Hongbin Ma, Xinghong Zhang, You Li   +3 more
doaj   +1 more source