Results 101 to 110 of about 947,560 (265)

Irrigation management strategies for winter wheat using AquaCrop model

Journal of Natural Resources and Development, 2013
Many regions of the world face the challenge to ensure high yield with limited water supply. This calls for utilization of available water in an efficient and sustainable manner. Quantitative models can assist in management decision and planning purposes.
M. H. Ali, I. Abustan
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Using stochastic dynamic programming to support weed management decisions over a rotation [PDF]

, 2009
This study describes a model that predicts the impact of weed management on the population dynamics of arable weeds over a rotation and presents the economic consequences.
Parsons, D. J., Milne, Alice E., Storkey, J., Lutman, P. J. W., Cussans, J., Benjamin, L. R., Parsons, David J., Milne, A. E.   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Gaussian process emulation to improve efficiency of computationally intensive multidisease models: a practical tutorial with adaptable R code

BMC Medical Research Methodology
Background The rapidly growing burden of non-communicable diseases (NCDs) among people living with HIV in sub-Saharan Africa (SSA) has expanded the number of multidisease models predicting future care needs and health system priorities.
Sharon Jepkorir Sawe, Richard Mugo, Marta Wilson-Barthes, Brianna Osetinsky, Stavroula A. Chrysanthopoulou, Faith Yego, Ann Mwangi, Omar Galárraga   +7 more
doaj   +1 more source

How Self-Stigma Fuels Negative Coping Strategies During COVID-19: Behavioral Pathways Through Negative Emotions and Motivational Impairment

Behavioral Sciences
From a social epidemiology perspective, this study examines self-stigma among COVID-19 quarantine populations and its influence on negative coping strategies. An online survey of 292 residents from quarantine and non-quarantine zones assessed self-stigma,
Yifeng Wang, Kan Shi, Shuhui Xu
doaj   +1 more source

Records of the Indian Sand Snake Psammophis condanarus (Merrem, 1820) (Reptilia: Lamprophiidae) in southern India

Journal of Threatened Taxa, 2017
We present new records of the Indian Sand Snake Psammophis condanarus from southern India, where its existence has remained doubtful till date.  Our records are based on both live and preserved voucher specimens that are illustrated and described here ...
S. R. Ganesh, Vivek Sharma, M. Bubesh Guptha   +2 more
doaj   +1 more source

Agricultural Model Intercomparison and Improvement Project (AgMIP) Datasets

, 2022
Site-based crop modeling data from field experiments, farm surveys, and yield trials. These data are in AgMIP harmonized format, ready for translation to multiple crop model formats using the data translation tools at http://tools.agmip.org/.
Agricultural Model Intercomparison and Improvement Project (AgMIP) (17477349)
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source