Results 91 to 100 of about 947,560 (265)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Harnessing dynamic capabilities for data-driven business model innovation in incumbents

Digital Business
Data-driven business model innovation (DDBMI) leverages digital technologies to seize opportunities and address challenges, yet incumbents often struggle due to their reliance on existing capabilities.
Shailesh Tripathi, Nadine Bachmann, Manuel Brunner, Herbert Jodlbauer   +3 more
doaj   +1 more source

Model-based Learning Assessment Management

, 2016
Model-based simulation and monitoring are becoming part of advanced learning environments. In this paper, we propose a model-based simulation and monitoring framework for management of learning assessment and we describe its architecture and main ...
Jorquera, Tom, Marchetti, Eda, Calabr?, Antonello, Zribi, Sarah, Lonetti, Francesca   +4 more
core  

Assessing the power of Porters' diamond model in the automobile industry in Mexico after ten years of NAFTA [PDF]

, 2005
vii, 102 leaves ; 29 cm.It has been ten years since the signature of the NAFTA agreement among Canada, U.S., and Mexico. For Mexico, this was a decisive step away from a protectionism model toward a free trade market.
University of Lethbridge. Faculty of Management, Barragan, Salvador   +1 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Comprehensive Management Model for Solid Waste Collection and Transportation in Peruvian Urban Municipalities

, 2019
El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.Here in, comprehensive management model of municipal solid waste collection and transportation, “MIGRU ...
Bernal, Renato, Edgar Sánchez, Mauricio, David, Renato Bernal, Sánchez, Edgar, David Mauricio, Carlos Raymundo, Raymundo, Carlos   +7 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Online Investor Sentiment via Machine Learning

Mathematics
In this paper, we propose utilizing machine learning methods to determine the expected aggregated stock market risk premium based on online investor sentiment and employing the multifold forward-validation method to select the relevant hyperparameters ...
Zongwu Cai, Pixiong Chen
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

To the end of the line – including intermediaries and end customers in the business model CANVAS

Journal of Open Innovation: Technology, Market and Complexity
The Business Model CANVAS is a widely adopted business model creation, visualization, and analysis framework. The CANVAS focuses on target customers but fails to consider the intermediaries situated between these target customers and end customers ...
Manuel Brunner, Nadine Bachmann, Ann-Kristin Thienemann, Alican Tuezuen, Herbert Jodlbauer   +4 more
doaj   +1 more source