Results 71 to 80 of about 947,560 (265)

The Linux managing model

First Monday, 2003
This study focuses on the distinguishing traits of the Linux managing model. It introduces the concept of process to capture the idea of impermanence, dissolvability and change. Far from being a predictable flow of programming, assembling and releasing activities, it is suggested that the Linux development process displays a stream of activities that ...
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Information-Theoretic Analysis of Bayesian Quantum State Search

IEEE Transactions on Quantum Engineering
We present an information-theoretic approach to quantum state classification based on sequential Bayesian inference. In each measurement step, the algorithm updates a probability distribution over candidate states by applying Bayes' rule to the ...
Zhelun Li, Koji Terashi
doaj   +1 more source

Designing a maturity model for analyzing information and knowledge management in the public sector

, 2020
PurposeThis study aims to report the design and testing of a maturity model for information and knowledge management in the public sector, intended for use in frequent monitoring, trend analysis and in-depth analysis of the contemporary information and ...
Jääskeläinen, Aki, Torkki, Paulus, Sillanpää, Virpi, Helander, Nina, Laasonen, Valtteri, Haavisto, Ira, Leskelä, Riikka-Leena   +6 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Seismic Risk Model for the Beijing–Tianjin–Hebei Region, China: Considering Epistemic Uncertainty from the Seismic Hazard Models

International Journal of Disaster Risk Science
This study presents a probabilistic seismic risk model for the Beijing–Tianjin–Hebei region in China. The model comprises a township-level residential building exposure model, a vulnerability model derived from the Chinese building taxonomy, and a ...
Jian Ma, Katsuichiro Goda, Kai Liu, Silva Vitor, Anirudh Rao, Ming Wang   +5 more
doaj   +1 more source

Preconditioning Large Indefinite Linear Systems

Sultan Qaboos University Journal for Science, 2011
After briefly recalling some relevant approaches for preconditioning large symmetric linear systems, we describe a novel class of preconditioners. Our proposal is tailored for large indefinite linear systems, which arise very frequently in many different
Giovanni Fasano, Massimo Roma
doaj   +1 more source

A guide to the project management body of knowledge: PMBOK guide

, 2013
A Guide to the Project Management Body of Knowledge (PMBOK Guide) Fifth Edition reflects the collaboration and knowledge of working project managers and provides the fundamentals of project management as they apply to a wide range of projects.
Project Management Institute
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source