Results 61 to 70 of about 4,793,633 (336)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Application of multiphysics model order reduction to doppler/neutronic feedback
EPJ Nuclear Sciences & Technologies, 2019 In this paper, a proper orthogonal decomposition based reduced-order model is presented for parametrized multiphysics computations. Our application physics is Doppler feedback in a simplified model of the molten salt fast reactor concept.
German Peter +2 more
doaj +1 more source
Results in Control and Optimization, 2023 Several approaches for reducing model order on the definite time segments have become the topic of investigation in a series of papers that bring challenges during application in a large-scale setting.
Xin Du +4 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
D6.2 - Model Order Reduction Toolbox
, 2022 This document reports about the Model Order Reduction, which we implemented in Task 6.2 and delivered as toolbox to the partners of the Upwards consortium. Partners use this toolbox for performing a rank reduction of models in the high dimensional data space of wind parks.
Adrian, Benjamin +2 more
openaire +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Basic principles and aims of model order reduction in compliant mechanisms [PDF]
Mechanical Sciences, 2011 Model order reduction appears to be beneficial for the synthesis and simulation of compliant mechanisms due to computational costs. Model order reduction is an established method in many technical fields for the approximation of large-scale linear time ...
M. Rösner, R. Lammering
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source