Results 91 to 100 of about 735,742 (300)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Promoting tissue repair with plant-derived compounds: evidence and mechanisms from zebrafish studies

Frontiers in Nutrition
The pursuit of strategies to enhance tissue repair is a central challenge in regenerative medicine, where plant-derived compounds offer immense therapeutic potential due to their multi-target, systems-level activities.
Xiang Meng, Xiang Meng, Xiang Meng, Xuting Song, Xuting Song, Xuting Song, Lixia Zhu, Lixia Zhu, Lixia Zhu, Yiming Wang, Yiming Wang, Yiming Wang, Xianghe Meng, Xianghe Meng, Yufang Tang, Yufang Tang, Kobil A. Bobokalonov, Min He, Min He, Min He, Mengmeng Sun, Mengmeng Sun, Mengmeng Sun, Meiying Jin, Meiying Jin   +24 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Non-linear bioconvection in a deep suspension of gyrotactic swimming micro-organisms [PDF]

, 1999
The non-linear structure of deep, stochastic, gyrotactic bioconvection is explored. A linear analysis is reviewed and a weakly non-linear analysis justifies its application by revealing the supercritical nature of the bifurcation. An asymptotic expansion
Hill, N., N A Hill, Bees, M., M A Bees
core  

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

, 2022
During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have been the primary model organisms used for the study of various biological phenomena.
Tolvanen, Martti E. E., Sly, William S., Barker, Harlan, Parkkila, Seppo, Purmonen, Sami, Syrjänen, Leo, Valanne, Susanna, Waheed, Abdul, Aspatwar, Ashok   +8 more
core   +1 more source

Evaluation of natural products bioactivity in cardiovascular diseases utilizing zebrafish models: a comprehensive review

Frontiers in Pharmacology
Cardiovascular diseases (CVDs) are a major global health challenge, significantly impacting public health and healthcare systems. Ethnopharmacological remedies and botanical medicines are widely used for the prevention and treatment of CVDs due to their ...
Yiming Wang, Yiming Wang, Yiming Wang, Xiang Meng, Xiang Meng, Xiang Meng, Xuting Song, Xuting Song, Xuting Song, Lulu Wang, Lulu Wang, Lulu Wang, Xianghe Meng, Xianghe Meng, Xiaoya Du, Ziyoviddin Yusupov, Komiljon Tojibaev, Yunpeng Wang, Min He, Min He, Min He, Mengmeng Sun, Mengmeng Sun, Mengmeng Sun   +23 more
doaj   +1 more source

Tardigrades and their emergence as model organisms

, 2022
Experimentally tractable organisms like C. elegans, Drosophila, zebrafish, and mouse are popular models for addressing diverse questions in biology. In 1997, two of the most valuable invertebrate model organisms to date – C. elegans and Drosophila – were found to be much more closely related to each other than expected. C.
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analysis of Coding Theory Based Models for Initiating Protein Translation in Prokaryotic Organisms

, 2002
Rapid advances in both genomic data acquisition and computational technology have encouraged the development and use of engineering methods in the field of bioinformatics and computational genomics.
May, Elebeoba Eni
core