Results 101 to 110 of about 2,691,356 (263)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development of a Novel Real-Time Weighted Surrogate Model for Wind Turbine-Based on DFIG: Enhancing Computational Efficiency in Power Systems With Error Bound

IEEE Access
In the realm of modern wind turbine engineering, where precision is paramount for stability, control, and observability, this article introduces a groundbreaking method leveraging time-weighted Gramians.
Muhammad Latif, Hira Ambreen, Tang Diyin, Farrukh Hassan, Muhammad Imran, Saddam Hussain Abbasi, Muhammad Imran   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Model Reduction in Parallelization Based on Equivalent Transformation of Block Bi-Diagonal Toeplitz Matrices for Two-Dimensional Discrete-Time Systems

Mathematics
This study proposes a parallel model reduction method for two-dimensional discrete-time systems, utilizing Krawtchouk moments and equivalent transformation. This work makes two significant contributions.
Zhen Li, Li-Hong Dong, Kang-Li Xu, Xiao-Yang Xu   +3 more
doaj   +1 more source

HillTau: A fast, compact abstraction for model reduction in biochemical signaling networks. [PDF]

PLoS Comput Biol, 2021
Bhalla US.
europepmc   +1 more source

Model reduction methods

, 2017
Peer ...
Chinesta, Francisco, Huerta, Antonio, Rozza, Gianluigi, Willcox, Karen   +3 more
openaire   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Model Reduction Captures Stochastic Gamma Oscillations on Low-Dimensional Manifolds. [PDF]

Front Comput Neurosci, 2021
Cai Y, Wu T, Tao L, Xiao ZC.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source