Results 101 to 110 of about 19,179,679 (309)

December 19, 2000

open access: yes, 2007
An adaptive model reduction algorithm is proposed for systems of ODEs from chemical kinetics. Its goal is to provide an accurate approximation to the solution of these systems faster than could be obtained through straightforward numerical integration.
Adaptive Model Reduction
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

On Model Reductions of Boolean Networks

open access: yes
Boolean networks are a class of qualitative models used ex-tensively to model regulatory interactions driving biological processes.While structurally simple, their dynamics can be quite complex. One re-current issue in studying the dynamics of these models is state explosion.To tackle this problem model reduction techniques are employed ...
Claudine Chaouiya   +2 more
openaire   +3 more sources

Balanced truncation model reduction of periodic systems [PDF]

open access: yes, 2000
The balanced truncation approach to model reduction is considered for linear discrete-time periodic systems with time-varying dimensions. Stability of the reduced model is proved and a guaranteed additive bound is derived for the approximation error ...
Varga, Andras
core  

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Model Reduction of LPV Control with Bounded Parameter Variation Rates [PDF]

open access: yes, 2006
This paper proposes a reduced-order controller of linear parameter varying systems. The parameters are available for measurement while their ranges and rates of variation are assumed to be bounded.
Riyanto, T. Bambang, Widowati, Widowati
core   +1 more source

Reduction of Markov Chains Using a Value-of-Information-Based Approach

open access: yesEntropy, 2019
In this paper, we propose an approach to obtain reduced-order models of Markov chains. Our approach is composed of two information-theoretic processes. The first is a means of comparing pairs of stationary chains on different state spaces, which is done ...
Isaac J. Sledge, José C. Príncipe
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Ion channel model reduction using manifold boundaries [PDF]

open access: yesJ R Soc Interface, 2022
Whittaker DG   +6 more
europepmc   +2 more sources

Entropy-Related Extremum Principles for Model Reduction of Dissipative Dynamical Systems

open access: yesEntropy, 2010
Chemical kinetic systems are modeled by dissipative ordinary differential equations involving multiple time scales. These lead to a phase flow generating anisotropic volume contraction.
Dirk Lebiedz
doaj   +1 more source

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