Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Machine Learning with ApplicationsThe application of deep neural networks towards solving problems in science and engineering has demonstrated encouraging results with the recent formulation of physics-informed neural networks (PINNs).
Jenny Farmer +3 more
doaj +1 more source
Inter-Rater Agreement in Assessing Risk of Bias in Melanoma Prediction Studies Using the Prediction Model Risk of Bias Assessment Tool (PROBAST): Results from a Controlled Experiment on the Effect of Specific Rater Training. [PDF]
J Clin Med, 2023 Kaiser I +7 more
europepmc +1 more source
Quantitative Risk Analysis for N-Methyl Pyrrolidone Using Physiologically Based Pharmacokinetic and Benchmark Dose Modeling [PDF]
, 2009 Torka S. Poet +5 more
openalex +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Infection rate models for COVID-19: Model risk and public health news sentiment exposure adjustments. [PDF]
PLoS One, 2021 Chalkiadakis I +3 more
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A Country Pandemic Risk Exposure Measurement Model
Risk Management and Healthcare Policy, 2020 Simon Grima,1 Murat Kizilkaya,2 Ramona Rupeika-Apoga,3 Inna Romānova,3 Rebecca Dalli Gonzi,4 Mihajlo Jakovljevic5– 7 1Department of Insurance, Faculty of Economics, Management and Accountancy, University of Malta, Msida, Malta; 2Department of ...
Grima S +5 more
doaj
Appraising prediction research: a guide and meta-review on bias and applicability assessment using the Prediction model Risk Of Bias ASsessment Tool (PROBAST). [PDF]
Nephrology (Carlton), 2021 de Jong Y +5 more
europepmc +1 more source