Results 71 to 80 of about 3,666,543 (317)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
A Risk Model with Delayed Claims [PDF]
Journal of Applied Probability, 2013 In this paper we introduce a simple risk model with delayed claims, an extension of the classical Poisson model. The claims are assumed to arrive according to a Poisson process and claims follow a light-tailed distribution, and each loss payment of the claims will be settled with a random period of delay.
Angelos Dassios, Hongbiao Zhao
openaire +2 more sources
Aggregate Risk Model and Risk Measure-Based Risk Allocation
InPrime, 2020 In actuarial modeling, aggregate risk is known as more attractive rather than individual risk. It has, however, usual difficulty in finding (the exact form of) joint probability distribution.
Khreshna Syuhada
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Credit risk prediction with and without weights of evidence using quantitative learning models
Cogent Economics & FinanceThe credit risk assessment process is necessary for maintaining financial stability, cost and time efficiency, model performance accuracy, comparability analysis and future business implications in the commercial banking sector.
Modisane B. Seitshiro, Seshni Govender
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Efficient Option Risk Measurement With Reduced Model Risk [PDF]
, 2016 Options require risk measurement that is also computationally efficient as it is important to derivatives risk management. There are currently few methods that are specifically adapted for efficient option risk measurement. Moreover, current methods rely
Mitra, S., Mitra, S, Mitra, Sovan
core +1 more source
The System of Forensic Activity Digitalization Theory
Теория и практика судебной экспертизыThe article examines the system of private theory of forensic activity digitalization from the standpoint of forensic expertology. The subject, objects, tasks of the theory and its place in forensic expertology are described.
E. R. Rossinskaya
doaj +1 more source
The communication strategy for the release of the first European Seismic Risk Model and the updated European Seismic Hazard Model [PDF]
Natural Hazards and Earth System SciencesTo design user-centred and scientifically high-quality outreach products to inform about earthquake-related hazards and the associated risk, a close collaboration between the model developers and communication experts is needed.
I. Dallo +21 more
doaj +1 more source