Results 71 to 80 of about 3,690,239 (301)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
IEEE AccessModel-driven development (MDD) in the Artificial Intelligence of Things (AIoT) domain faces significant challenges in ensuring the consistency and preservation of model properties during transformations, often leading to system inconsistencies.
Gullelala Jadoon +6 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
A Linda-based Platform for the Parallel Execution of Out-place Model Transformations [PDF]
, 2017 Context: The performance and scalability of model transformations is gaining interest as industry is progressively adopting model-driven techniques and multicore computers are becoming commonplace.
Burgueño, Loli +2 more
core
Solving the TTC 2011 Reengineering Case with VIATRA2
, 2011 The current paper presents a solution of the Program Understanding: A Reengineering Case for the Transformation Tool Contest using the VIATRA2 model transformation tool.Comment: In Proceedings TTC 2011, arXiv:1111 ...
András Balogh +11 more
core +2 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Revista EIA, 2008 Actualmente en los ambientes de desarrollo de software hay un gran interés en buscar y desarrollar técnicas que puedan integrar los sistemas transaccionales con los flujos de trabajo que soportan los procesos del negocio de las organizaciones.
Marta Silvia Tabares +2 more
doaj
Exact Solutions and Degenerate Properties of Spin Chains with Reducible Hamiltonians
, 2018 The Jordan--Wigner transformation plays an important role in spin models. However, the non-locality of the transformation implies that a periodic chain of $N$ spins is not mapped to a periodic or an anti-periodic chain of lattice fermions. Since only the
Fan, Shiung
core +1 more source
FE calculations on a three stage metal forming process of Sandvik Nanoflex [PDF]
, 2004 Sandvik NanoflexTM combines good corrosion resistance with high strength. This steel has good deformability in\ud austenitic conditions. It belongs to the group of metastable austenites, which means that during deformation a strain-induced\ud ...
Huetink, J. +3 more
core +3 more sources