Results 81 to 90 of about 24,109,276 (315)
Complex Systems Informatics and Modeling Quarterly, 2017 System thinking has become an effective strategy when dealing with complex systems. Such systems are characterized by mutual interactions, causality and inter-dependency between system components. A typical example is the cooperation between governmental
Maryam M. Khamis, Theo P. van der Weide
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Workflow Generation from the Two-Hemisphere Model
Applied Computer Systems, 2017 Model-Driven Software Development (MDSD) is a trend in Software Development that focuses on code generation from various kinds of models. To perform such a task, it is necessary to develop an algorithm that performs source model transformation into the ...
Gusarovs Konstantīns +1 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Using Business Analytics for SME Business Model Transformation under Pandemic Time Pressure. [PDF]
Inf Syst Front, 2022 Zamani ED, Griva A, Conboy K.
europepmc +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Dynamically Integrating OSM Data into a Borderland Database
ISPRS International Journal of Geo-Information, 2015 Spatial data are fundamental for borderland analyses of geography, natural resources, demography, politics, economy, and culture. As the spatial data used in borderland research usually cover the borderland regions of several neighboring countries, it is
Xiaoguang Zhou +4 more
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Anemic Domain Model vs Rich Domain Model to Improve the Two-Hemisphere Model-Driven Approach
Applied Computer Systems, 2020 Evolution of software development process and increasing complexity of software systems calls for developers to pay great attention to the evolution of CASE tools for software development.
Nikiforova Oksana, Gusarovs Konstantins
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From Bureaucratic Coordination to a Data-Driven Model: Transformation and Capacity Building of Community-Based Prevention and Control of Public Health Events. [PDF]
Int J Environ Res Public Health, 2022 Xian M, Zhao C, Zhou Y.
europepmc +1 more source