Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
MODELING OF ANIMATED SIMULATIONS BY MAXIMA PROGRAM TOOLS
Інформаційні технології і засоби навчання, 2015 The article deals with the methodical features in training of computer simulation of systems and processes using animation. In the article the importance of visibility of educational material that combines sensory and thinking sides of cognition is noted.
Nataliya O. Bugayets
doaj
Leveraging Business Modeling Tools For Ecosystemic Business Model Design
Journal of Business ModelsBusiness modeling tools are crucial for designing and implementing successful business models. However, there exist instances—which we refer to as the design of ecosystemic business models—in which developing a business model requires simultaneous ...
Christian Vorbohle, Dennis Kundisch
doaj +1 more source
Combining cross-section images and modeling tools to create high-resolution root system hydraulic atlases in Zea mays. [PDF]
Plant Direct, 2021 Heymans A, Couvreur V, Lobet G.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Letter to the Editor: Can Predictive Modeling Tools Identify Patients at High Risk of Prolonged Opioid Use After ACL Reconstruction? [PDF]
Clin Orthop Relat Res, 2021 Wang Q, Zhu H.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Reply to the Letter to the Editor: Can Predictive Modeling Tools Identify Patients at High Risk of Prolonged Opioid Use after ACL Reconstruction? [PDF]
Clin Orthop Relat Res, 2021 Anderson AB +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source