Results 91 to 100 of about 28,765,428 (344)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pre-Processing and Modeling Tools for Bigdata

Foundations of Computing and Decision Sciences, 2016
Modeling tools and operators help the user / developer to identify the processing field on the top of the sequence and to send into the computing module only the data related to the requested result.
Hashem Hadi, Ranc Daniel
doaj   +1 more source

Data modeling of deep-sky images

, 2004
We present a method for simulating CCD focal plane array (FPA) images of extended deep sky objects using Data Modeling. Data Modeling is a process of deriving functional equations from measured data. These tools are used to model FPA fixed pattern noise,
Edwards, Matthew, James Handley, Hons, Alex, Albert Lim, Holger Jaenisch, Graeme White, Miroslav Filipovic, Alex Hons, Matthew Edwards, Cullum, Martin J., Handley, James, Lim, Albert, Jaenisch, Holger M., White, Graeme, Filipovic, Miroslav, White, Graeme L., Lim, Albert C., Craig, Simon C., Jaenisch, Holger   +18 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Translation of Real-Time Infectious Disease Modeling into Routine Public Health Practice

Emerging Infectious Diseases, 2017
Infectious disease dynamic modeling can support outbreak emergency responses. We conducted a workshop to canvas the needs of stakeholders in Australia for practical, real-time modeling tools for infectious disease emergencies.
David J. Muscatello, Abrar A. Chughtai, Anita Heywood, Lauren M. Gardner, David J. Heslop, C. Raina MacIntyre   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Theories: Tools versus models [PDF]

Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Suárez, Mauricio, Cartwright, Nancy
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modeling and Simulation Tools for Fog Computing—A Comprehensive Survey from a Cost Perspective

Future Internet, 2020
Fog computing is an emerging and evolving technology, which bridges the cloud with the network edges, allowing computing to work in a decentralized manner. As such, it introduces a number of complex issues to the research community and the industry alike.
Spiridoula V. Margariti, Vassilios V. Dimakopoulos, Georgios Tsoumanis   +2 more
doaj   +1 more source