Results 81 to 90 of about 5,613,073 (287)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Deriving Usability Evaluation Criteria for Threat Modeling Tools

IEEE Access
As the domestic and international landscape rapidly changes, the importance of implementing security measures in response to the growing threats that businesses face has increased.
Inno Hwang, Hyunsuk Cho, Seungjoo Kim
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

New tools for learning about war and postwar problems, : a guide to films, pamphlets and recordings, for teachers, speakers, and discussion leaders.

, 1943
Supplemented by: Supplement ... (1 v. 20 cm.) published: [New York, N.Y., New tools for learning, 1944-] Call number: D746.3 .N4 Suppl."Annotated list of materials available": p.
New Tools for Learning.
core  

Designing tools for oil exploration using nuclear modeling

EPJ Web of Conferences, 2017
When designing nuclear tools for oil exploration, one of the first steps is typically nuclear modeling for concept evaluation and initial characterization.
Mauborgne Marie-Laure, Allioli Françoise, Manclossi Mauro, Nicoletti Luisa, Stoller Chris, Evans Mike   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Supporting Focus and Context Awareness in 3D Modeling Using Multi-Layered Displays [PDF]

, 2013
Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years.
Mohd Yusof, Azmi
core  

Flood Modeling by GIS Tools

Journal of New Results in Science, 2018
Study area Samsun/Atakumprovince is almost under threat of flooding in each year. In this region, themain reason of devastating flood is the influence of the Degirmen streamespecially during March, April, and July and due to seasonal rainfall ...
Asli Ulke, Vahdettin Demir, Neslihan Beden   +2 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source