Results 101 to 110 of about 5,613,073 (287)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Don’t Adapt Small Language Models for Tools; Adapt Tool Schemas to the Models
Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)Small language models (SLMs) enable scalable tool-augmented multi-agent systems where multiple SLMs handle subtasks orchestrated by a powerful coordinator. However, they struggle with tool-use tasks, particularly in selecting appropriate tools and identifying correct parameters.
Jonggeun Lee +4 more
openaire +3 more sources
Determining the Predominant Conformations of Mortiamides A-D in Solution Using NMR Data and Molecular Modeling Tools. [PDF]
ACS Omega, 2023 Franca TCC +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Computer Modeling Tools for EMC
, 1996 Computer modeling tools for EMC analysis generally fall into one of three categories: numerical modeling codes, analytical modeling codes, or design rule checkers.
Drewniak, James L., Hubing, Todd H.
core +1 more source
Neural organoids as advanced tools for neurotoxicity modeling
Current Research in ToxicologyNeurotoxicity studies often depend on traditional cell-based monoculture assays and animal models, which have a number of limitations. In particular, the existing models either lack the appropriate physiological context, do not include a functional blood–
Joydeb Majumder, William L. Murphy
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Evaluating reduced-form modeling tools for simulating ozone and PM<sub>2.5</sub> monetized health impacts. [PDF]
Environ Sci Atmos, 2023 Simon H +11 more
europepmc +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source