Results 71 to 80 of about 341,194 (266)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A structured evaluation of genome-scale constraint-based modeling tools for microbial consortia. [PDF]

PLoS Comput Biol, 2023
Scott WT, Benito-Vaquerizo S, Zimmermann J, Bajić D, Heinken A, Suarez-Diez M, Schaap PJ.   +6 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Determining the Predominant Conformations of Mortiamides A-D in Solution Using NMR Data and Molecular Modeling Tools. [PDF]

ACS Omega, 2023
Franca TCC, Goncalves ADS, Bérubé C, Voyer N, Aubry N, LaPlante SR.   +5 more
europepmc   +1 more source

ATL: A model transformation tool

Science of Computer Programming, 2008
AbstractIn the context of Model Driven Engineering, models are the main development artifacts and model transformations are among the most important operations applied to models. A number of specialized languages have been proposed, aimed at specifying model transformations.
Jouault, Frédéric, Allilaire, Freddy, Bézivin, Jean, Kurtev, Ivan   +3 more
openaire   +4 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Editorial: Data driven modeling in mathematical biology

Frontiers in Applied Mathematics and Statistics, 2023
Jacques Demongeot, Pierre Magal
doaj   +1 more source

Simulation modeling tools in training environmental science students

Вісник Харківського національного університету імені В.Н. Каразіна: Серія Екологія
The use of computer modeling and forecasting for the analysis and prediction of complex systemic processes, particularly in the field of environmental protection, is extremely important.
А. G. Kot, A. B. Achasov, O. Yu. Seliverstov, V. G. Karpov   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Evaluating reduced-form modeling tools for simulating ozone and PM_2.5 monetized health impacts. [PDF]

Environ Sci Atmos, 2023
Simon H, Baker KR, Sellers J, Amend M, Penn SL, Bankert J, Chan EAW, Fann N, Jang C, McKinley G, Zawacki M, Roman H.   +11 more
europepmc   +1 more source