Results 51 to 60 of about 1,269,111 (343)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

The estimation and translation uncertainties in applying NOAEL to clinical dose escalation

Clinical and Translational Science
The systemic exposure at the no‐observed‐adverse‐effect‐level (NOAEL) estimated from animals is an important criterion commonly applied to guard the safety of participants in clinical trials of investigational drugs.
Chao Chen, Silvia Maria Lavezzi, David McDougall   +2 more
doaj   +1 more source

Variations in Muscle Activity and Exerted Torque During Temporary Blood Flow Restriction in Healthy Individuals

Frontiers in Bioengineering and Biotechnology, 2021
Recent studies suggest that transitory blood flow restriction (BFR) may improve the outcomes of training from anatomical (hypertrophy) and neural control perspectives.
Leonardo Gizzi, Utku Ş. Yavuz, Dominic Hillerkuss, Tommaso Geri, Elena Gneiting, Franziska Domeier, Syn Schmitt, Syn Schmitt, Oliver Röhrle, Oliver Röhrle   +9 more
doaj   +1 more source

Using multilevel random coefficient models to assess students’ spelling abilities [PDF]

, 2010
This paper presents statistical models that analyze cross- sectional data related to student attainment in English and Maltese spelling. For each spelling test a random sample of 2040 students, whose age ranged from 6.5 to 16 years, was selected to ...
Camilleri, Liberato, Firman, Christine, Martinelli, Victor, The European Simulation and Modelling Conference (ESM'2010), Ventura, Frank   +4 more
core  

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

The Development of the Use of Expert Testimony [PDF]

, 1935
The steadily increasing performance of modern computer systems is having a large influence on simulation technologies. It enables increasingly detailed simulations of larger and more comprehensive simulation models.
Rosenthal, Lloyd L.
core   +1 more source

Modelling and simulation of advanced semiconductor devices [PDF]

, 2017
This paper presents a modelling and simulation study of advanced semiconductor devices. Different Technology Computer Aided Design approaches and models, used in nowadays research are described here.
Adamu-Lema, Fikru, Al-Ameri, T., Asenov, Asen, Berrada, Salim, Duan, Meng, Georgiev, Vihar, Lee, Jaehyun   +6 more
core   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Practical challenges in data‐driven interpolation: Dealing with noise, enforcing stability, and computing realizations

International Journal of Adaptive Control and Signal Processing, EarlyView., 2023
Summary In this contribution, we propose a detailed study of interpolation‐based data‐driven methods that are of relevance in the model reduction and also in the systems and control communities. The data are given by samples of the transfer function of the underlying (unknown) model, that is, we analyze frequency‐response data.
Quirin Aumann, Ion Victor Gosea
wiley   +1 more source

Coupled thermal and mechanical analysis of composite cross sections using mathematical optimization strategies

Engineering Structures and Technologies, 2017
In the present article an alternative approach for the coupled thermal and mechanical analysis of composite cross sections under temperature effects is introduced, which uses the mathematical optimization as a consistent methodical base.
Christopher Taube, Hans-Georg Timmler, Marcel Helmrich, Guido Morgenthal   +3 more
doaj   +1 more source