Results 71 to 80 of about 1,269,111 (343)

Modelling iteration in engineering design [PDF]

open access: yes, 2007
This paper examines design iteration and its modelling in the simulation of New Product Development (NPD) processes. A framework comprising six perspectives of iteration is proposed and it is argued that the importance of each perspective depends upon ...
Clarkson, PJ, Eckert, CM, Wynn, DC
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Simulation of extreme temperature over Odisha during May 2015

open access: yesWeather and Climate Extremes, 2017
An extreme temperature event (heat wave) over the state of Odisha was unique as it lasted for about 2 weeks in the 3rd and 4th weeks of May 2015. There was a similar severe heat wave in western and central Odisha in the month of April 1998.
K.C. Gouda   +3 more
doaj   +1 more source

Improving Thermochemical Energy Storage Dynamics Forecast with Physics-Inspired Neural Network Architecture

open access: yesEnergies, 2020
Thermochemical Energy Storage (TCES), specifically the calcium oxide (CaO)/calcium hydroxide (Ca(OH)2) system is a promising energy storage technology with relatively high energy density and low cost. However, the existing models available to predict the
Timothy Praditia   +3 more
doaj   +1 more source

Transportation Centrality: Quantifying the Relative Importance of Nodes in Transportation Networks Based on Traffic Modeling

open access: yesIEEE Access, 2023
The topology of transportation networks such as road and rail networks determines the efficiency and effectiveness of the corresponding transport systems. Quantifying the relative importance of nodes of such networks is vital to understand their dynamics.
Mahendra Piraveenan   +1 more
doaj   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Decision makers\u27 experience of participatory dynamic simulation modelling: Methods for public health policy [PDF]

open access: yes, 2018
Background: Systems science methods such as dynamic simulation modelling are well suited to address questions about public health policy as they consider the complexity, context and dynamic nature of system-wide behaviours.
Atkinson, Jo-An   +4 more
core   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

open access: yesFEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui   +5 more
wiley   +1 more source

Convolutional Neural Network-Based Digital Diagnostic Tool for the Identification of Psychosomatic Illnesses

open access: yesAlgorithms
This paper appraises convolutional neural network (CNN) models’ capabilities in emotion detection from facial expressions, seeking to aid the diagnosis of psychosomatic illnesses, typically made in clinical setups.
Marta Narigina   +2 more
doaj   +1 more source

An Error Indicator-Based Adaptive Reduced Order Model for Nonlinear Structural Mechanics—Application to High-Pressure Turbine Blades

open access: yesMathematical and Computational Applications, 2019
The industrial application motivating this work is the fatigue computation of aircraft engines’ high-pressure turbine blades. The material model involves nonlinear elastoviscoplastic behavior laws, for which the parameters depend on the temperature.
Fabien Casenave, Nissrine Akkari
doaj   +1 more source

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