Results 51 to 60 of about 4,097 (260)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

3D-printed anatomic models of the knee for evaluation of patellofemoral dysplasia in comparison to standard radiographs and computed tomography

open access: yes, 2020
PURPOSE To evaluate 3D-printed anatomic models of the distal femur and patella for diagnosis and classification of patellofemoral dysplasia in comparison to conventional radiographs (CR) and CT.
Fritz, Benjamin   +5 more
core   +1 more source

3D printing and urology: Review of the clinical applications

open access: yesУкраїнський Журнал Нефрології та Діалізу, 2020
Three-dimensional (3D) printing is a process that translates a 3D virtual model into its physical 3D replica. In medicine, Neurosurgery, Orthopedics and Maxillo-facial surgery were the first specialties to successfully incorporate this technology in ...
K. Wendo, R. Olszewski
doaj   +1 more source

Exposer la collection anatomique de l’École des beaux-arts de Dresde

open access: yesIn Situ, 2021
Dresden University of Fine Arts (HfBK) is, with the École nationale des beaux-arts de Paris, one of the two academies of Fine Arts in Europe that possesses an old and very rich collection for artistic anatomy. The anatomy collection of Dresden University
Sandra Mühlenberend   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Benchmarking Academic Anatomic Pathologists

open access: yes, 2016
The most common benchmarks for faculty productivity are derived from Medical Group Management Association (MGMA) or Vizient-AAMC Faculty Practice Solutions Center ® (FPSC) databases.
Tristram Parslow MD, PhD   +1 more
core   +1 more source

From "silent teachers" to models [PDF]

open access: yes, 2014
For decades, embalmed cadavers have played an important role in teaching anatomy to the scientists and doctors of the future. Most anatomy departments use a traditional formaldehyde-based embalming method, but formalin embalming makes the bodies very ...
Wilkinson, Tracey   +5 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Methods for reasoning from geometry about anatomic structures injured by penetrating trauma

open access: yes, 2006
This paper presents the methods used for three-dimensional (3D) reasoning about anatomic structures affected by penetrating trauma in TraumaSCAN-Web, a platform-independent decision support system for evaluating the effects of penetrating trauma to the ...
Ogunyemi, Omolola
core   +1 more source

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