Results 71 to 80 of about 24,674,172 (349)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deep Learning-based Prescription of Cardiac MRI Planes. [PDF]

open access: yes, 2019
PurposeTo develop and evaluate a system to prescribe imaging planes for cardiac MRI based on deep learning (DL)-based localization of key anatomic landmarks.Materials and methodsAnnotated landmarks on 892 long-axis (LAX) and 493 short-axis (SAX) cine ...
Bahrami, Naeim   +4 more
core  

Individual differences in human path integration abilities correlate with gray matter volume in retrosplenial cortex, hippocampus, and medial prefrontal cortex [PDF]

open access: yes, 2017
Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures.
Aselcioglu, Irem   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

3D computerized model for measuring strain and displacement of the brachial plexus following placement of reverse shoulder prosthesis [PDF]

open access: yes, 2008
The aim of the present study was to develop a method for three-dimensional (3D) reconstruction of the brachial plexus to study its morphology and to calculate strain and displacement in relation to changed nerve position.
Audenaert, Emmanuel   +5 more
core   +1 more source

Digitalni anatomski model lubanje psa

open access: yesVeterinar, 2020
A digital 3D model of a canine skull was designed to serve as an additional aid, alongside books and other resources and learning material. The available textbooks only provide a 2D view, using photos and illustrations and they often do not display the entire bone and have flawed descriptions.
Marić, Marija   +4 more
openaire   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Morphometric differences between basal cell carcinomas & melanomas of the head & neck versus other sites and their influence on neural networks

open access: yesEJC Skin Cancer
Background: Dermoscopic appearance of basal cell carcinomas (BCC) and melanomas guide diagnosis and may be influenced by anatomic location. Objective: We aimed to investigate the morphometric differences between anatomic sites of the head and neck(H&N ...
Jonas Hue   +3 more
doaj   +1 more source

Visualization of back pain data-A 3-D solution [PDF]

open access: yes, 2007
Traditional approaches to gathering and visualizing pain data rely on two-dimensional (2-D) human body models, where different types of sensation are recorded with various monochrome symbols.
Chana, G, Frank, AO, Ghinea, G, Kent, S
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

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