Results 71 to 80 of about 4,097 (260)

Towards anatomic scale agent-based modeling with a massively parallel spatially explicit general-purpose model of enteric tissue (SEGMEnT_HPC). [PDF]

PLoS ONE, 2015
Perhaps the greatest challenge currently facing the biomedical research community is the ability to integrate highly detailed cellular and molecular mechanisms to represent clinical disease states as a pathway to engineer effective therapeutics.
Robert Chase Cockrell, Scott Christley, Eugene Chang, Gary An   +3 more
doaj   +1 more source

Anatomical Modelling of the Pregnant Radiotherapy Patient [PDF]

, 2015
This study aimed to take existing anatomical models of pregnant women, currently used for radiation protection and nuclear medicine dose calculations, and adapt them for use in the calculation of fetal dose from external beam radiotherapy (EBRT). The models investigated were ‘KATJA’, which was provided as an MCNPX geometry file, and ‘RPI-P6’, which was
Kairn, Tanya, Crowe, Scott, Mitchell, J., Schlect, David, Trapp, Jamie   +4 more
openaire   +4 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Low-cost synthetic model for training and simulation of nipple-areola complex (NAC) reconstruction [PDF]

Revista Brasileira de Cirurgia Plástica
Introduction: Reconstruction of the nipple-areola complex (NAC) is indicated when this member is amputated in mastectomies to ensure a more natural appearance to the reconstructed breast.
Pedro Lucena de Aquino, Arthur Antunes Coimbra Pinheiro Pacífico, Letícia Fontenelle Fernandes, Giselle Ferreira de Souza, Sarah Gurgel Ponte Fontenelle, Ana Heloísa Feitosa de Macêdo Pereira, Pâmella Christine de Souza Munhoz, Letícia Castelo Branco de Oliveira   +7 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Anatomic Position Determines Oncogenic Specificity in Melanoma

, 2021
Oncogenic alterations to DNA are not transforming in all cellular contexts. This may be due to pre-existing transcriptional programs in the cell of origin.
Weiss, Joshua
core  

Disrupted anatomic networks in the 22q11.2 deletion syndrome

, 2016
The 22q11.2 deletion syndrome (22q11DS) is an uncommon genetic disorder with an increased risk of psychosis. Although the neural substrates of psychosis and schizophrenia are not well understood, aberrations in cortical networks represent intriguing ...
Kosha Ruparel, MS, J. Eric Schmitt, MD PhD, Amy Cassidy, MS, Monica E. Calkins, PhD, Ruben C. Gur, PhD, Margaret C. Souders, PhD CRNP, Raquel E. Gur, MD PhD, David R. Roalf, PhD, Elaine H. Zackai, MD, James Yi, MD PhD, Beverly S. Emanuel, PhD, Donna M. McDonald-McGinn, MS CGC, Theodore D. Satterthwaite, MD MA   +12 more
core   +2 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Anatomic-sex interaction effects and prognostic stratification in mucoepidermoid carcinoma of the oral cavity minor salivary glands

Discover Oncology
Background To investigate the impact of anatomic-sex interaction effects on survival outcomes in mucoepidermoid carcinoma (MEC) of the oral cavity minor salivary glands.
Hongya Zheng, Lin He, Yue Song, Shuang Zhao, Shuang Pan, Shuang Zhang   +5 more
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source