Results 61 to 70 of about 4,097 (260)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

European risk models for morbidity (EuroLung1) and mortality (EuroLung2) to predict outcome following anatomic lung resections: an analysis from the European Society of Thoracic Surgeons database

, 2017
To develop models of 30-day mortality and cardiopulmonary morbidity from data on anatomic lung resections deposited in the European Society of Thoracic Surgeons (ESTS) database.status ...
Falcoz, Pierre Emmanuel, Brunelli, Alessandro, Rocco, Gaetano, Varela, Gonzalo, Decaluwé, Herbert, Van Raemdonck, Dirk, Salati, Michele   +6 more
core   +1 more source

Morphometric differences between basal cell carcinomas & melanomas of the head & neck versus other sites and their influence on neural networks

EJC Skin Cancer
Background: Dermoscopic appearance of basal cell carcinomas (BCC) and melanomas guide diagnosis and may be influenced by anatomic location. Objective: We aimed to investigate the morphometric differences between anatomic sites of the head and neck(H&N ...
Jonas Hue, Jinendra Ekanayake, Jamshid Dehmeshki, Jagtar Dhanda   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Ultrasound mapping of soft tissue vascular anatomy proximal to the larynx: a prospective cohort study [PDF]

Korean Journal of Anesthesiology
Background Bleeding incidents during percutaneous dilatational tracheostomy are concerning, and most cases occur in patients with unrecognized and unanticipated anatomical variations in the vascular anatomy.
Alessandro De Cassai, Margherita Iuzzolino, Silvia De Pinto, Giovanni Zecchino, Tommaso Pettenuzzo, Annalisa Boscolo, Eugenio Biamonte, Paolo Navalesi, Marina Munari   +8 more
doaj   +1 more source

Anatomical foundation models for brain MRIs

Pattern Recognition Letters
Updated version; added ablation ...
Barbano C. A., Brunello M., Dufumier B., Grangetto M.   +3 more
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Precise Anatomic Localization of Accumulated Lipids in Mfp2 Deficient Murine Brains Through Automated Registration of SIMS Images to the Allen Brain Atlas [PDF]

, 2015
Mass spectrometry imaging (MSI) is a powerful tool for the molecular characterization of specific tissue regions. Histochemical staining provides anatomic information complementary to MSI data.
Khmelinskii, Artem, Heeren, Ron M. A., Karolina Škrášková, Abdelmoula, W.M., Munter, S. de, Heeren, Ron M.A., Baes, M., Heeren, R.M.A. (Ron), Baes, Myriam, Liam Mcdonnell, Dijkstra, J., Dijkstra, Jouke, Heeren, R.M.A., McDonnell, Liam, Abdelmoula, Walid M., De Munter, S., Skraskova, Karolina, Myriam Baes, Ron M. A. Heeren, De Munter, Stephanie, Skraskova, K., Walid M. Abdelmoula, Dijkstra, J. (Jouke), Jouke Dijkstra, McDonnell, L., Khmelinskii, A., Artem Khmelinskii, Stephanie De Munter   +27 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

From Tuscany to Vienna: Paolo Mascagni's anatomic models in the Josephinum

, 2019
Paolo Mascagni (Pisa 1755-Siena 1815) was one of the major members of the cultural and scientific community in Tuscany in the XIX century. After initial interest in geological investigations, he successfully turned his attention to medical sciences.
Scatena, Cristian, Naccarato, Antonio Giuseppe   +1 more
core   +1 more source