Results 21 to 30 of about 26,772,730 (350)

Animal Models of GWAS-Identified Type 2 Diabetes Genes [PDF]

, 2013
More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D).
Bellomo, EA, French, PM, McGinty, JA, Rutter, GA, Xavier, GDS   +4 more
core   +1 more source

Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

Environmental Health Perspectives, 2000
Vulnerable periods during the development of the nervous system are sensitive to environmental insults because they are dependent on the temporal and regional emergence of critical developmental processes (i.e., proliferation, migration, differentiation,
D. Rice, S. Barone
semanticscholar   +1 more source

Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system

Stem Cell Research, 2023
The RAN Guanine Nucleotide Release Factor (RANGRF) gene encodes the protein MOG1, which binds to Nav1.5 and facilitates its transport to the cell membrane. Nav1.5 mutations have been linked to various cardiac arrhythmias and cardiomyopathy.
Meiling Jiang, Chengcheng Tang, Xian Luo, Xiaoqing Zhou, Min Chen, Yue Chi, Liangxue Lai, Qingjian Zou   +7 more
doaj   +1 more source

1st INCF Workshop on Genetic Animal Models for Brain Diseases [PDF]

, 2011
The INCF Secretariat organized a workshop to focus on the “role of neuroinformatics in the processes of building, evaluating, and using genetic animal models for brain diseases” in Stockholm, December 13–14, 2009.
Holm Graessner, Olaf Riess
core   +2 more sources

TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens

Nature Communications, 2021
TARM1 is a LILR family member that drives cell signalling via interactions with FcRγ. Here the authors show that TARM1 binds collagens to activate dendritic cells and thereby is an effector of inflammatory arthritis, plus provide a soluble TARM-Fc fusion
Rikio Yabe, Soo-Hyun Chung, Masanori A. Murayama, Sachiko Kubo, Kenji Shimizu, Yukiko Akahori, Takumi Maruhashi, Akimasa Seno, Tomonori Kaifu, Shinobu Saijo, Yoichiro Iwakura   +10 more
doaj   +1 more source

Mathematical modelling in animal nutrition: a centenary review [PDF]

, 2008
A centenary review presents an opportunity to ponder over the processes of concept development and give thought to future directions. The current review aims to ascertain the ontogeny of current concepts, underline the connection between ideas and people
A. DUMAS, Armsby, Atwater, Baldwin, Baldwin, Beever, Bergman, Black, Black, Blaxter, Blaxter, Blaxter, Brody, Brody, Bureau, Curnow, Davidson, de Lange, Dent, Dijkstra, Ewing, Feller, Forbes, Forbes, Garfinkel, Garrett, Gayon, Headley, Henneberg, Hill, Hubbell, Hungate, J. DIJKSTRA, J. FRANCE, Johnson, Jull, Kellner, Kellner, Kevles, Kleiber, Kleiber, Koehler, Kriss, Kronfeld, Kyriazakis, Lehmann, Lerner, Lotka, Maynard, Maynard, McCollum, McCollum, Mercer, Michaelis, Mignon-Grasteau, Mitchell, Mitchell, Mitchell, Mitscherlich-Königsberg, Monod, Morris, Moulton, Murray, Nelson, Osborne, Osborne, Oslage, Pearl, Pirt, Porter, Ragsdale, Ratkowski, Ratkowski, Rice, Riley, Ritzman, Robertson, Robertson, Rubner, Schiemann, Schinckel, Schneider, Seber, Steele, Thaer, Thomas, Thorbek, Thornley, Tyler, Vande Wiele, Verhulst, Waters, Wenk, Weymouth, Wolff, Wolff   +95 more
core   +2 more sources

The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation

Frontiers in Immunology, 2021
C1q/TNF-related proteins (CTRP) including CTRP3 are a group of secreted proteins which have a complement C1q-like domain in common, and play versatile roles in lipid metabolism, inflammation, tumor metastasis and bone metabolism.
Masanori A. Murayama, Masanori A. Murayama, Hsi-Hua Chi, Mako Matsuoka, Takahiro Ono, Yoichiro Iwakura   +5 more
doaj   +1 more source

Validating Animal Models [PDF]

, 2015
This paper responds to a recent challenge for the validity of extrapolation of neurobiological knowledge from laboratory animals to humans. According to this challenge, experimental neurobiology, and thus neuroscience, is in a state of crisis because the
Atanasova, Nina
core   +6 more sources

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [PDF]

, 2013
Key Points First report demonstrating in vivo elimination of multiple LIC populations from childhood ALL cases using animal models. In vivo models of leukemia are essential for drug evaluation studies.
Blair, Allison, Cox, Charlotte V, Diamanti, Paraskevi, Moppett, John P   +3 more
core   +2 more sources

Animal models of major depression: drawbacks and challenges

Journal of neural transmission, 2019
Major depression is a leading contributor to the global burden of disease. This situation is mainly related to the chronicity and/or recurrence of the disorder, and to poor response to antidepressant therapy.
Barbara Planchez, A. Surget, C. Belzung
semanticscholar   +1 more source