Results 71 to 80 of about 26,772,730 (350)
Cancer Cell InternationalLysosomes, as crucial organelles within cells, carry out diverse biological functions such as waste degradation, regulation of the cellular environment, and precise control of cell signaling.
Jianlei Bi +7 more
doaj +1 more source
Antioxidants, 2022 Vitamin C (vitC) deficiency has been associated with an increased risk of cardiovascular disease; while several putative mechanistic links have been proposed, functional evidence supporting a causal relationship is scarce.
Gry Freja Skovsted +5 more
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Improving translational studies: lessons from rare neuromuscular diseases [PDF]
, 2015 Animal models play a key role in the development of novel treatments for human disease. This is particularly true for rare diseases – defined as disorders that affect less than 1 in 2000 people in the human population – for which, very often, there are ...
Wells, D J
core +3 more sources
Developmental Disorders in Children Recently Diagnosed With Cancer
Pediatric Blood &Cancer, EarlyView.ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag +5 more
wiley +1 more source
Animal models in biological and biomedical research - experimental and ethical concerns.
Anais da Academia Brasileira de Ciências, 2019 Animal models have been used in experimental research to increase human knowledge and contribute to finding solutions to biological and biomedical questions.
M. Andersen, L. M. F. Winter
semanticscholar +1 more source
AnimalsOocyte quality is crucial for successful fertilization and subsequent embryonic development. Post-ovulatory aging leads to reduced oocyte quality and impaired embryogenesis, representing an unavoidable challenge in terms of certain assisted reproductive ...
Jia-Jun Ren +7 more
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Development and validation of Triticum phytobiological method as an alternative procedure for investigating in vivo acute toxicity on mice [PDF]
, 2017 The goal of this study was to validate an alternative method for determining in vivo acute toxicity using vegetal material instead of laboratory animals, starting from the phytobiological method known also as the Triticum technique.
Anghel, Adriana +5 more
core +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker +7 more
wiley +1 more source
Floor plate-derived dopamine neurons from hESCs efficiently engraft in animal models of PD
Nature, 2011 Human pluripotent stem cells (PSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. However,
Sonja Kriks +15 more
semanticscholar +1 more source
A compact, versatile drug-induced splicing switch system with minimal background expression
Cell Reports: MethodsSummary: Gene-switch techniques hold promising applications in contemporary genetics research, particularly in disease treatment and genetic engineering.
Yue Chi +12 more
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