Results 111 to 120 of about 30,009,286 (350)

Stability of a neural network model with small-world connections

, 2004
Small-world networks are highly clustered networks with small distances among the nodes. There are many biological neural networks that present this kind of connections.
C. Aguirre, C. F. Moukarzel, C. W. Wu, Chunguang Li, D. J. Watts, Guanrong Chen, H. Hong, J. G. White, L. F. Lago-Fernández, M. Barahona, M. E. J. Newman, M. E. J. Newman, M. Joy, P. M. Gade, X. F. Wang, X. Liao   +15 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives

Molecules, 2016
The search for new molecular constructs that resemble the critical two-metal binding pharmacophore and the halo-substituted phenyl functionality required for HIV-1 integrase (IN) inhibition represents a vibrant area of research within drug discovery.
Guan-Nan Liu, Rong-Hua Luo, Yu Zhou, Xing-Jie Zhang, Jian Li, Liu-Meng Yang, Yong-Tang Zheng, Hong Liu   +7 more
doaj   +1 more source

Computational Methods and Results for Structured Multiscale Models of Tumor Invasion

, 2005
We present multiscale models of cancer tumor invasion with components at the molecular, cellular, and tissue levels. We provide biological justifications for the model components, present computational results from the model, and discuss the scientific ...
Anderson, Alexander R. A., Ayati, Bruce P., Webb, Glenn F.   +2 more
core  

Biological constraints on neural network models of cognitive function

Nature Reviews Neuroscience, 2021
F. Pulvermüller, Rosario Tomasello, Malte R. Henningsen-Schomers, T. Wennekers   +3 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A novel dual DYRK1A/B inhibitor for the treatment of type 1 diabetes

Frontiers in Pharmacology
BackgroundType 1 diabetes (T1D) is an autoimmune disease that leads to the progressive destruction of pancreatic β cells, resulting in insulin deficiency and hyperglycemia. Current treatments focus on insulin replacement, but novel therapeutic approaches
Šarūnas Tumas, Jonas Mingaila, Vytautas Baranauskas, Vytautas Baranauskas, Emilija Baltrukonytė, Laurynas Orla, Jan Aleksander Krasko, Roberta Pocevičiūtė, Dina Berlina, Alexei Belenky, Maria Vilenchik, Agnė Vaitkevičienė, Olga Potapova, Aurelijus Burokas   +13 more
doaj   +1 more source

Main Biological Models of Resilience.

Clinical neuropsychiatry
Resilience is a complex process of adaptation to new conditions that would permit a positive outcome after adversities, traumas or other sources of stress. However, despite the growing interest in this topic, there is no universally accepted definition and no comprehensive bio-behavioural model. This systematic review aims to provide an overview of the
Donatella Marazziti, Sara Fantasia, Stefania Palermo, Alessandro Arone, Lucia Massa, Matteo Gambini, Claudia Carmassi   +6 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source