Results 111 to 120 of about 24,835,738 (277)

The Role of Representation in Biological Modeling

, 2021
Should every transcript and protein be faithfully reconstructed from data, or is it enough to include only those elements for which we are familiar? Or is it enough for the model to be metaphoric in nature, only loosely resembling the problem domain? When considering a biological system, it is important to consider what is the most appropriate level of
openaire   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Capturing the essence of folding and functions of biomolecules using Coarse-Grained Models

, 2011
The distances over which biological molecules and their complexes can function range from a few nanometres, in the case of folded structures, to millimetres, for example during chromosome organization. Describing phenomena that cover such diverse length,
A Dhar, A Elcock, A Elcock, A Grosberg, A Grosberg, A Minton, A Pisliakov, A Podtelezhnikov, A Rychkova, A Savelyev, A Vologodskii, AA Podtelezhnikov, B Messer, BJ Alder, C Bustamante, C Clementi, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, C Hyeon, D Thirumalai, D Thirumalai, D Thirumalai, D Thirumalai, D Thirumalai, E Koculi, E Lieberman-Aiden, E O'Brien, E Shakhnovich, EP O'Brien, F Valle, G Lorimer, G Papoian, G Ziv, H Liu, H Ma, HX Zhou, I Tinoco Jr., J Chen, J Harms, J Karanicolas, J Straub, JD Honeycutt, JM Fernandez, JN Onuchic, KA Dill, M Levitt, M Mickler, M Strajbl, M Takano, ME Fisher, MJ Todd, MS Cheung, N Hirokawa, N Koga, N Toan, OK Dudko, P Weinkam, PB Moore, PC Whitford, Q Du, R Russell, R Tehver, R Tehver, RD Vale, RD Vale, RI Dima, RW Pastor, S Jun, S Jun, S Jun, S Kamerlin, S Kirkpatrick, S Moghaddam, SB Smith, SJ Chen, SJ Marrink, T Cloutier, T Cremer, T Kirkpatrick, T Veitshans, V Lubchenko, Z Liu, Z Xu   +89 more
core   +1 more source

CMOS circuit implementations for neuron models [PDF]

, 1990
The mathematical neuron basic cells used as basic cells in popular neural network architectures and algorithms are discussed. The most popular neuron models (without training) used in neural network architectures and algorithms (NNA) are considered ...
Linares Barranco, Bernabé, Rodríguez Vázquez, Ángel Benito, Sánchez Sinencio, Edgar   +2 more
core   +1 more source

Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems

Database J. Biol. Databases Curation, 2015
With the wealth of publications and data available, powerful and transparent computational approaches are required to represent measured data and scientific knowledge in a computable and searchable format. We developed a set of biological network models,
S. Boué, M. Talikka, J. Westra, W. Hayes, Anselmo Di Fabio, Jennifer Park, W. Schlage, A. Sewer, Brett Fields, Sam Ansari, F. Martin, E. Veljkovic, Renée Kenney, M. Peitsch, J. Hoeng   +14 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Unraveling the Dynamics of Host–Microbiota Indole Metabolism: An Investigation of Indole, Indolin-2-one, Isatin, and 3-Hydroxyindolin-2-one

Molecules
The gut microbiota produces a variety of bioactive molecules that facilitate host–microbiota interaction. Indole and its metabolites are focused as possible biomarkers for various diseases.
Arnas Kunevičius, Mikas Sadauskas, Julija Raudytė, Rolandas Meškys, Aurelijus Burokas   +4 more
doaj   +1 more source

3D Microporous Scaffolds Manufactured via Combination of Fused Filament Fabrication and Direct Laser Writing Ablation

Micromachines, 2014
A 3D printing fused filament fabrication (FFF) approach has been implemented for the creation of microstructures having an internal 3D microstructure geometry. These objects were produced without any sacrificial structures or additional support materials,
Mangirdas Malinauskas, Sima Rekštytė, Laurynas Lukoševičius, Simas Butkus, Evaldas Balčiūnas, Milda Pečiukaitytė, Daiva Baltriukienė, Virginija Bukelskienė, Arūnas Butkevičius, Povilas Kucevičius, Vygandas Rutkūnas, Saulius Juodkazis   +11 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Draft genome sequence data of Lactiplantibacillus plantarum 33C isolated from Lithuanian fermented food

Data in Brief
This strain was isolated from traditionally (homemade) fermented Lithuanian cherry tomatoes. The genome consists of 55 contigs with a total size of 3,326,119 bp, an N50 of 170738, and a GC% of 44.3 %.
Ashwinipriyadarshini Megur, Eglė Lastauskienė, Aurelijus Burokas   +2 more
doaj   +1 more source