Results 151 to 160 of about 24,835,738 (277)
Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases
FEBS Letters, EarlyView.
Igor Zivkovic +2 more
wiley +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Growth and yield models for eucalyptus stands obtained by differential equations
Scientia Agricola: The main purpose of this study was to assess nonlinear models generated by integrating the basal area growth rate to estimate the growth and yield of forest stands.
Adriano Ribeiro de Mendonça +3 more
doaj +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Biological Models in Frontotemporal Dementias
, 2008 Publisher Summary This chapter describes that neurofibrillary tangles (NFT) are, with senile plaques, the hallmark neuropathological lesions used for the neuropathological diagnosis of Alzheimer's disease. The intensity of these lesions, particularly NFT, is correlated with the severity of the dementing syndrome.
openaire +4 more sources
Modelling counts in biological populations
Mathematical and Computer Modelling, 1989 Summary: The relationship between the number of species in a genus in a region and the area of this region is a topic much debated by biologists. Two models, namely the power function model and the exponential model have received most attention in the literature.
openaire +3 more sources
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Nature Communications, 2019 Hypoxia occurs at high altitude and in cancer. Here, the authors show that a gene involved in hypoxia, YTHDF1, underwent rapid evolution in Tibetans and their domestic animals, and find that the gene is amplified in some cancers and contributes to drug ...
Yulin Shi +20 more
doaj +1 more source