Results 51 to 60 of about 3,531,989 (315)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
From stellar nebula to planetesimals [PDF]
, 2014 Solar and extrasolar comets and extrasolar planets are the subject of numerous studies in order to determine their chemical composition and internal structure.
Alibert, Yann +4 more
core +2 more sources
Kaemika app, Integrating protocols and chemical simulation [PDF]
arXiv, 2020 Kaemika is an app available on the four major app stores. It provides deterministic and stochastic simulation, supporting natural chemical notation enhanced with recursive and conditional generation of chemical reaction networks. It has a liquid-handling protocol sublanguage compiled to a virtual digital microfluidic device.
arxiv
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Advanced ScienceTumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with the ability to modulate receptor tyrosine kinase (RTK ...
Alican Kuşoğlu +23 more
doaj +1 more source
Bayesian joint modeling of chemical structure and dose response curves [PDF]
, 2019 Today there are approximately 85,000 chemicals regulated under the Toxic Substances Control Act, with around 2,000 new chemicals introduced each year. It is impossible to screen all of these chemicals for potential toxic effects either via full organism in vivo studies or in vitro high-throughput screening (HTS) programs.
arxiv +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Galactic chemical evolution: Stellar yields and the initial mass function [PDF]
, 2015 We present a set of 144 Galactic chemical evolution models applied to a Milky Way analogue, computed using four sets of low+intermediate star nucleosynthetic yields, six massive star yield compilations, and six functional forms for the initial mass ...
Cavichia, Oscar +4 more
core +4 more sources
MedCommColorectal cancer (CRC) is one of the most common malignancies worldwide. In the clinical realm, platinum‐based drugs hold an important role in the chemotherapy of CRC.
Wei Li +9 more
doaj +1 more source
Classification of Current Experimental Models of Epilepsy
Brain SciencesIntroduction: This article provides an overview of several experimental models, including in vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models, that have been employed to investigate epileptogenesis. The present
Carmen Rubio +3 more
doaj +1 more source