Results 201 to 210 of about 26,076,796 (269)

Machine Learning and Mendelian Randomization Identify Allergic Rhinitis as Nasopharyngeal Carcinoma Risk Factor With Validated Potential Candidate Biomarkers. [PDF]

Int J Genomics
Chen M, Yang B, Gong C, Liao X, He K, Li Z.   +5 more
europepmc   +1 more source

Patient-derived xenograft models: an emerging platform for translational cancer research.

Cancer Discovery, 2014
M. Hidalgo, F. Amant, A. Biankin, E. Budinská, A. Byrne, C. Caldas, R. Clarke, S. de Jong, J. Jonkers, G. Mælandsmo, S. Roman-Roman, J. Seoane, L. Trusolino, A. Villanueva   +13 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploring diversity: a review of animal models for investigating variations in sex characteristics. [PDF]

Front Pediatr
de Faria Oliveira G, Niepsuj T, Gupta A, Auger AP.   +3 more
europepmc   +1 more source

Evaluating loci for use in the genetic analysis of population structure

Proceedings of the Royal Society of London. Series B: Biological Sciences, 1996
M. Beaumont, R. Nichols
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Artificial intelligence-driven metabolomics of retinal nerve fibre layer to profile risks of mortality and cardiometabolic diseases. [PDF]

Nat Commun
Yang S, Xin Z, Li H, Zhu Z, Zhu LZ, Shang X, Huang W, Zhang L, He M, Jonas JB, Congdon N, Cheng CY, Liang L, Wang W.   +13 more
europepmc   +1 more source

General quantitative genetic methods for comparative biology: phylogenies, taxonomies and multi‐trait models for continuous and categorical characters

Journal of Evolutionary Biology, 2010
J. Hadfield, S Nakagawa
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Harnessing genomic prediction in Brassica napus through a nested association mapping population. [PDF]

Plant Genome
Perumal S, Higgins EE, Sra S, Khedikar Y, Moore J, Chaudary R, Haile T, Koh CS, Vail S, Robinson SJ, Horner K, Hope B, Klein-Gebbinck H, Herrmann DT, Navabi K, Sharpe AG, Parkin IAP.   +16 more
europepmc   +1 more source