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Multi-modal AI in precision medicine: integrating genomics, imaging, and EHR data for clinical insights. [PDF]
Front Artif IntellKhan SN +4 more
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Integrated genomic analysis of a diverse maize population reveals novel genes and superior predictive models for ear diameter. [PDF]
BMC GenomicsWu X +6 more
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Pharmacogenomics, 2002
The inference of genetic interactions from measured expression data is one of the most challenging tasks of modern functional genomics. When successful, the learned network of regulatory interactions yields a wealth of useful information. An inferred genetic network contains information about the pathway to which a gene belongs and which genes it ...
E P, van Someren +3 more
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The inference of genetic interactions from measured expression data is one of the most challenging tasks of modern functional genomics. When successful, the learned network of regulatory interactions yields a wealth of useful information. An inferred genetic network contains information about the pathway to which a gene belongs and which genes it ...
E P, van Someren +3 more
openaire +2 more sources
Mathematical models in genetics
Russian Journal of Genetics, 2016In this study, we present some of the basic ideas of population genetics. The founders of population genetics are R.A. Fisher, S. Wright, and J. B.S. Haldane. They, not only developed almost all the basic theory associated with genetics, but they also initiated multiple experiments in support of their theories.
M, Traykov, Iv, Trenchev
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Congenital glaucoma: Genetic models
Human Genetics, 1979Modes of inheritance of congenital glaucoma have been studied. Two methods of analysis, complex segregation analysis and frequency of congenital glaucoma in second- and third-degree relatives, did not permit one to retain a unitary mode of inheritance ofthis malformation. Genetic heterogeneity of congenital glaucoma is proposed.
F, Demenais +4 more
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Genetic models of carcinogenesis
Human Pathology, 1983The major genetic models of carcinogenesis are critically reviewed to determine their validity and relevance for clinical and experimental oncologists. Of major concern are the "two-hit" theory of Knudson and the host resistance system of Matsunaga. These models may be used to explain the pathobiologic peculiarities of human neoplasms, particularly ...
R P, Bolande, M J, Vekemans
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Genetic Models in Pathogenesis
Annual Review of Genetics, 2004▪ Abstract To decipher the complexity of host-pathogen interactions the widest possible range of model hosts and of analytical methods is required. As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases.
Elizabeth, Pradel, Jonathan J, Ewbank
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Genetic polymorphisms and additive genetic models
Behavior Genetics, 1985The degree of genetic dissimilarity between inbred strains or substrains of mice may be estimated from available data concerning biochemical and immunological polymorphisms. Dissimilarities between substrains are bimodally distributed, suggesting that both genetic drift and contamination are responsible for substrain differences.
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Adapting genetic regulatory models by genetic programming
Biosystems, 2004In this paper, we focus on the task of adapting genetic regulatory models based on gene expression data from microarrays. Our approach aims at automatic revision of qualitative regulatory models to improve their fit to expression data. We describe a type of regulatory model designed for this purpose, a method for predicting the quality of such models ...
R, Eriksson, B, Olsson
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