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Science, 2000
P opulation genetics relies heavily on mathematical modeling to make quantitative predictions about the behavior of genes in populations. These models are based on the principles of classic Mendelian gene inheritance; the Hardy-Weinberg equilibrium law, which predicts the gene frequency in a population; and Darwin's theory of natural selection ...
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P opulation genetics relies heavily on mathematical modeling to make quantitative predictions about the behavior of genes in populations. These models are based on the principles of classic Mendelian gene inheritance; the Hardy-Weinberg equilibrium law, which predicts the gene frequency in a population; and Darwin's theory of natural selection ...
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1977
Consider a population consisting of 2N genes at a single locus (N diploid individuals) which are either A or a, where N is fixed number.
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Consider a population consisting of 2N genes at a single locus (N diploid individuals) which are either A or a, where N is fixed number.
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Alcohol and genetics: New models
American Journal of Medical Genetics, 2002AbstractAlcoholism is a complex genetic trait; susceptibility is influenced by multiple genes of small effect. To pursue mechanistic studies, genetic animal models have been used. These models are partial, each addressing one or more of the contributing traits rather than the disease as a whole.
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Genetic models in applied physiology
Journal of Applied Physiology, 2003We are in a genomic revolution, and many of the major advances in applied physiology are based on discoveries made with genetic model systems. These model systems provide not only an in-depth understanding of normal human physiology but also serve as models of human disease.
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