Results 71 to 80 of about 25,171,962 (340)

A Genetic Porcine Model of Cancer

PLOS ONE, 2015
The large size of the pig and its similarity in anatomy, physiology, metabolism, and genetics to humans make it an ideal platform to develop a genetically defined, large animal model of cancer. To this end, we created a transgenic "oncopig" line encoding Cre recombinase inducible porcine transgenes encoding KRASG12D and TP53R167H, which represent a ...
Eric M. Walters, Kevin D. Wells, Tiago Collares, Christopher M. Counter, Randall S. Prather, Fabiana Kömmling Seixas, Lawrence B. Schook, Ying Liang, Laurie A. Rund, Kyle M. Schachtschneider, Kuldeep Singh, Wenping Hu, Fernanda Martins Rodrigues   +12 more
openaire   +5 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation

BMC Biology
Background The tree shrew (Tupaia belangeri) is a promising emerging model organism in biomedical studies, notably due to their evolutionary proximity to primates.
Dongmin R. Son, Yifan Kong, Yulian Tan, Ting Hu, Lei Shi, Soojin V. Yi   +5 more
doaj   +1 more source

Genetic models of Parkinson disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
To date, a truly representative animal model of Parkinson disease (PD) remains a critical unmet need. Although toxin-induced PD models have served many useful purposes, they have generally failed to recapitulate accurately the progressive process as well as the nature and distribution of the human pathology.
Chee-Hoe Ng, Kah-Leong Lim
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling

Nature Communications
While canonical Wnt signaling is well recognized for its crucial regulatory functions in cell fate decisions, the role of non-canonical Wnt signaling in adult stem cells remains elusive and contradictory.
Xing Yang, Haibo Xu, Xu Yang, Hui Wang, Li Zou, Qin Yang, Xiaopeng Qi, Li Li, Hongxia Duan, Xiyun Yan, Nai Yang Fu, Jing Tan, Zongliu Hou, Baowei Jiao   +13 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Author Correction: 547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates

Genome Biology, 2020
Following publication of the original paper [1], the authors reported an error in the affiliation of Xin-Tian Hu, who is also affiliated with “Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan ...
Ming-Li Li, Shi-Hao Wu, Jin-Jin Zhang, Hang-Yu Tian, Yong Shao, Zheng-Bo Wang, David M. Irwin, Jia-Li Li, Xin-Tian Hu, Dong-Dong Wu   +9 more
doaj   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

FEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa, Cong Lin, Irina A. Talyzina, Marina V. Goncharuk, Eduard V. Bocharov, Alexander S. Arseniev, Xiaohui Wang, Sergey A. Goncharuk, Konstantin S. Mineev   +8 more
wiley   +1 more source

Comparative Phylogeography of Two Specialist Rodents in Forest Fragments in Kenya

Life
The fragmented forests of the Kenya highlands, known for their exceptional species richness and endemism, are among the world’s most important biodiversity hotspots. However, detailed studies on the fauna of these ecosystems—especially specialist species
Alois Wambua Mweu, Kenneth Otieno Onditi, Laxman Khanal, Simon Musila, Esther Kioko, Xuelong Jiang   +5 more
doaj   +1 more source