Results 11 to 20 of about 3,509,714 (267)
In silico design and evaluation of a multi-epitope and multi-antigenic African swine fever vaccine
ImmunoInformatics, 2022 African Swine Fever (ASF) is caused by a highly contagious and fatal hemorrhagic virus, which in 2019 alone in Asia, has killed 8 million pigs with a devastating estimated economic loss amounting to $130 billion.
Ara Karizza G. Buan +3 more
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ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis
Scientific Reports, 2021 ADAM10 and ADAM17 are proteases that affect multiple signalling pathways by releasing molecules from the cell surface. As their substrate specificities partially overlaps, we investigated their concurrent role in liver regeneration and fibrosis, using ...
Olga Zbodakova +6 more
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CD166-specific CAR-T cells potently target colorectal cancer cells
Translational Oncology, 2023 Chimeric antigen receptor (CAR) T-cell therapy is emerging as an effective cancer treatment, such as for hematological malignancies, however its effectiveness as an approach to treat solid tumors, such as in colorectal cancer (CRC), remains to be better ...
Shuai He +8 more
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BMC Gastroenterology, 2022 Background Ubiquitin ligases (Ub-ligases) are essential intracellular enzymes responsible for the regulation of proteome homeostasis, signaling pathway crosstalk, cell differentiation and stress responses.
Veronika Iatsiuk +8 more
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Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate
Frontiers in Cell and Developmental Biology, 2021 WIZ (Widely Interspaced Zinc Finger) is associated with the G9a-GLP protein complex, a key H3K9 methyltransferase suggesting a role in transcriptional repression. However, its role in embryonic development is poorly described. In order to assess the loss
Ivana Bukova +6 more
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CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review
Cells, 2020 Imprinting diseases (IDs) are rare congenital disorders caused by aberrant dosages of imprinted genes. Rare IDs are comprised by a group of several distinct disorders that share a great deal of homology in terms of genetic etiologies and symptoms ...
Linn Amanda Syding +3 more
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Translational Oncology, 2021 Drug repurposing is used as a strategy for finding new drugs for cancer. The process is a faster and a more cost-effective way of providing new indications for drugs that can address emerging drug resistance and numerous side effects of chemotherapeutic ...
Paul Mark Medina +2 more
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Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions
Scientific Reports, 2023 Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in multiple independent lineages ...
Frantisek Spoutil +13 more
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Molecular mimicry and cancer vaccine development
Molecular Cancer, 2023 Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte +6 more
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BEAST: Bayesian evolutionary analysis by sampling trees [PDF]
, 2007 Background The evolutionary analysis of molecular sequence variation is a statistical enterprise. This is reflected in the increased use of probabilistic models for phylogenetic inference, multiple sequence alignment, and molecular population genetics ...
Drummond, Alexei J., Rambaut, Andrew
core +3 more sources