Results 11 to 20 of about 27,132,286 (267)

Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns

BMC Gastroenterology, 2022
Background Ubiquitin ligases (Ub-ligases) are essential intracellular enzymes responsible for the regulation of proteome homeostasis, signaling pathway crosstalk, cell differentiation and stress responses.
Veronika Iatsiuk, Frantisek Malinka, Marketa Pickova, Jolana Tureckova, Jiri Klema, Frantisek Spoutil, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek   +8 more
doaj   +1 more source

Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate

Frontiers in Cell and Developmental Biology, 2021
WIZ (Widely Interspaced Zinc Finger) is associated with the G9a-GLP protein complex, a key H3K9 methyltransferase suggesting a role in transcriptional repression. However, its role in embryonic development is poorly described. In order to assess the loss
Ivana Bukova, Katarzyna Izabela Szczerkowska, Michaela Prochazkova, Inken M. Beck, Inken M. Beck, Jan Prochazka, Radislav Sedlacek   +6 more
doaj   +1 more source

CRISPR/Cas9 Epigenome Editing Potential for Rare Imprinting Diseases: A Review

Cells, 2020
Imprinting diseases (IDs) are rare congenital disorders caused by aberrant dosages of imprinted genes. Rare IDs are comprised by a group of several distinct disorders that share a great deal of homology in terms of genetic etiologies and symptoms ...
Linn Amanda Syding, Petr Nickl, Petr Kasparek, Radislav Sedlacek   +3 more
doaj   +1 more source

Torsional Diffusion for Molecular Conformer Generation [PDF]

Neural Information Processing Systems, 2022
Molecular conformer generation is a fundamental task in computational chemistry. Several machine learning approaches have been developed, but none have outperformed state-of-the-art cheminformatics methods.
Bowen Jing, Gabriele Corso, Jeffrey Chang, R. Barzilay, T. Jaakkola   +4 more
semanticscholar   +1 more source

Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions

Scientific Reports, 2023
Highly specialized enamel matrix proteins (EMPs) are predominantly expressed in odontogenic tissues and diverged from common ancestral gene. They are crucial for the maturation of enamel and its extreme complexity in multiple independent lineages ...
Frantisek Spoutil, Goretti Aranaz-Novaliches, Michaela Prochazkova, Tomas Wald, Vendula Novosadova, Petr Kasparek, Radim Osicka, Janne E. Reseland, Staale P. Lyngstadaas, Hanna Tiainen, Kristyna Bousova, Jiri Vondrasek, Radislav Sedlacek, Jan Prochazka   +13 more
doaj   +1 more source

Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains

Translational Oncology, 2021
Drug repurposing is used as a strategy for finding new drugs for cancer. The process is a faster and a more cost-effective way of providing new indications for drugs that can address emerging drug resistance and numerous side effects of chemotherapeutic ...
Paul Mark Medina, Jozelle Marie Ponce, Christian Alfredo Cruz   +2 more
doaj   +1 more source

Molecular Sets (MOSES): A Benchmarking Platform for Molecular Generation Models [PDF]

Frontiers in Pharmacology, 2018
Generative models are becoming a tool of choice for exploring the molecular space. These models learn on a large training dataset and produce novel molecular structures with similar properties.
Daniil A Polykovskiy, Alexander Zhebrak, Benjamín Sánchez-Lengeling, Sergey Golovanov, Oktai Tatanov, Stanislav Belyaev, Rauf Kurbanov, A. Artamonov, V. Aladinskiy, M. Veselov, Artur Kadurin, S. Nikolenko, Alán Aspuru-Guzik, A. Zhavoronkov   +13 more
semanticscholar   +1 more source

Molecular mimicry and cancer vaccine development

Molecular Cancer, 2023
Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Franco M. Buonaguro, Maria Lina Tornesello, Luigi Buonaguro   +6 more
doaj   +1 more source

GuacaMol: Benchmarking Models for De Novo Molecular Design [PDF]

Journal of Chemical Information and Modeling, 2018
De novo design seeks to generate molecules with required property profiles by virtual design-make-test cycles. With the emergence of deep learning and neural generative models in many application areas, models for molecular design based on neural ...
Nathan Brown, Marco Fiscato, Marwin H. S. Segler, Alain C. Vaucher   +3 more
semanticscholar   +1 more source

Molecular docking as a tool for the discovery of molecular targets of nutraceuticals in diseases management

Scientific Reports, 2023
Molecular docking is a computational technique that predicts the binding affinity of ligands to receptor proteins. Although it has potential uses in nutraceutical research, it has developed into a formidable tool for drug development.
P. Agu, C. Afiukwa, O. U. Orji, E. Ezeh, I. H. Ofoke, C. Ogbu, E. Ugwuja, P. M. Aja   +7 more
semanticscholar   +1 more source