Results 31 to 40 of about 3,509,714 (267)

Chimeric Antigen Receptor T Cells Targeting Cell Surface GRP78 to Eradicate Acute Myeloid Leukemia

open access: yesFrontiers in Cell and Developmental Biology, 2022
Acute myeloid leukemia (AML) is a serious, life-threatening hematological malignancy. The treatment outcome of relapsed or refractory AML patients remains dismal, and new treatment options are needed.
Wei Yu   +6 more
doaj   +1 more source

Antigenic molecular mimicry in viral-mediated protection from cancer: the HIV case

open access: yesJournal of Translational Medicine, 2022
Background People living with HIV/AIDS (PLWHA) show a reduced incidence for three cancer types, namely breast, prostate and colon cancers. In the present study, we assessed whether a molecular mimicry between HIV epitopes and tumor associated antigens ...
Carmen Manolio   +10 more
doaj   +1 more source

Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Ube3a Gene

open access: yesCells, 2022
Angelman syndrome (AS) is a neurodevelopmental disorder caused by deficits in maternally inherited UBE3A. The disease is characterized by intellectual disability, impaired motor skills, and behavioral deficits, including increased anxiety and autism ...
Linn Amanda Syding   +7 more
doaj   +1 more source

Behaviour of microscale gas flows based on a power-law free path distribution function [PDF]

open access: yes, 2011
We investigate a power-law form for the probability distribution function of free paths of dilute gas molecules in a confined region. A geometry-dependent effective molecular mean free path (MFP) model is then derived for a planar wall confinement, by ...
Dongari, Nishanth   +2 more
core   +1 more source

Molecular modeling

open access: yesJournal of Pharmacy And Bioallied Sciences, 2009
The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to ...
Aarti Sharma, Himanshu Gupta
openaire   +2 more sources

Transferable atomic multipole machine learning models for small organic molecules [PDF]

open access: yes, 2015
Accurate representation of the molecular electrostatic potential, which is often expanded in distributed multipole moments, is crucial for an efficient evaluation of intermolecular interactions.
Andrienko, Denis   +2 more
core   +4 more sources

Molecular-orbital representation of generic flat-band models

open access: yes, 2019
We develop a framework to describe a wide class of flat-band models, with and without a translational symmetry, by using "molecular orbitals" introduced in the prior work (HATSUGAI Y. and MARUYAMA I., \textit{EPL}, \textbf{95}, (2011) 20003).
Hatsugai, Yasuhiro, Mizoguchi, Tomonari
core   +1 more source

Complexity of Restricted and Unrestricted Models of Molecular Computation [PDF]

open access: yes, 1996
In [9] and [2] a formal model for molecular computing was proposed, which makes focused use of affinity purification. The use of PCR was suggested to expand the range of feasible computations, resulting in a second model.
Winfree, Erik
core   +2 more sources

Molecular Dynamics Study of Polarizable Ion Models for Molten AgBr [PDF]

open access: yes, 2006
Three different polarizable ion models for molten AgBr have been studied by molecular dynamics simulations. The three models are based on a rigid ion model (RIM) with a pair potential of the type proposed by Vashishta and Rahman for alpha-AgI, to which ...
Bitrian, V., Trullas, J.
core   +1 more source

Extended master equation models for molecular communication networks

open access: yes, 2013
We consider molecular communication networks consisting of transmitters and receivers distributed in a fluidic medium. In such networks, a transmitter sends one or more signalling molecules, which are diffused over the medium, to the receiver to realise ...
Chou, Chun Tung
core   +1 more source

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