Results 41 to 50 of about 3,509,714 (267)

Application of a Spacer-nick Gene-targeting Approach to Repair Disease-causing Mutations with Increased Safety

Bio-Protocol, 2023
The CRISPR/Cas9 system is a powerful tool for gene repair that holds great potential for gene therapy to cure monogenic diseases. Despite intensive improvement, the safety of this system remains a major clinical concern.
Ngoc Tung Tran, Mikhail Lebedin, Eric Danner, Ralf Kühn, Klaus Rajewsky, Van Trung Chu   +5 more
doaj   +1 more source

LIME - a flexible, non-LTE line excitation and radiation transfer method for millimeter and far-infrared wavelengths [PDF]

, 2010
We present a new code for solving the molecular and atomic excitation and radiation transfer problem in a molecular gas and predicting emergent spectra.
Bordag, Michael, Lambiase, G., Nesterenko, V.V.   +2 more
core   +1 more source

Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

Journal of Translational Medicine, 2023
Background Glioblastoma (GBM) is recognized as among the most aggressive forms of brain tumor. Patients typically present with a five-year survival rate of less than 6% with traditional surgery and chemoradiotherapy, which calls for novel immunotherapies
Shijie Wang, Wenwen Wei, Yuncang Yuan, Bin Sun, Dong Yang, Nan Liu, Xudong Zhao   +6 more
doaj   +1 more source

Turbulent Driving Scales in Molecular Clouds

, 2009
Supersonic turbulence in molecular clouds is a dominant agent that strongly affects the clouds' evolution and star formation activity. Turbulence may be initiated and maintained by a number of processes, acting at a wide range of physical scales.
Anathpindika, Ballesteros-Paredes, Ballesteros-Paredes, Bally, Banerjee, Basu, Bergin, Brunt, Brunt, Brunt, Brunt, Brunt, C. M. Brunt, Dale, Dobbs, Elmegreen, Elmegreen, Falgarone, Glover, Goldsmith, Hartmann, Heitsch, Heyer, Heyer, Heyer, Heyer, Kim, Klessen, Knee, Koda, Larson, Lazarian, Lazarian, M. H. Heyer, M.-M. Mac Low, Mac Low, Mac Low, Mac Low, Matzner, Miesch, Offner, Ossenkopf, Ostriker, Pan, Price, Quillen, Ridge, Ridge, Rosolowsky, Scalo, Schneider, Shu, Stone, Stone, Stone, Swift, Walawender   +56 more
core   +1 more source

Tapuy lees attenuate amyloid-β toxicity and dopaminergic neurodegeneration more effectively than Tapuy wine in C. elegans models of Alzheimer’s and Parkinson’s disease

Discover Food
Tapuy is a traditional rice wine from the Philippines. We explored the potential of Tapuy wine and its fermentation by-product, lees, in reducing amyloid-beta toxicity in Alzheimer’s disease (AD) and dopaminergic neurodegeneration in Parkinson’s disease (
Mark Joseph R. Remucal, Junelle Rey C. Bacong, Paul Mark B. Medina   +2 more
doaj   +1 more source

Molecular Modeling [PDF]

, 1994
Molecular Modeling: From Virtual Tools to Real Problems Reliability of X-Ray Crystallographic Structures Determining the Solution Conformation of Receptor-Bound Ligands by NMR: A Transferred Nuclear Overhauser Effect Study of the Peptidyl Prolyl Cis-Trans Isomerase Cyclophilin and a Model Substrate Modeling Biologically Relevant Peptides Using Circular
openaire   +1 more source

Interstellar Turbulence and Star Formation [PDF]

, 2010
We provide a brief overview of recent advances and outstanding issues in simulations of interstellar turbulence, including isothermal models for interior structure of molecular clouds and larger-scale multiphase models designed to simulate the formation ...
Alexei G. Kritsuk, Audit, de Avillez, Federrath, Folini, Frisch, Hennebelle, Klessen, Kritsuk, Kritsuk, Kritsuk, Michael L. Norman, Nicolis, Niklaus, Price, Rosas-Guevara, Schmidt, Sergey D. Ustyugov, Vázquez-Semadeni, Walder   +19 more
core   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

The lees extracts of Philippine rice wine (Tapuy) protect transgenic Caenorhabditis elegans from glyphosate-induced neurotoxicity

Food Production, Processing and Nutrition
Tapuy is an indigenous rice wine traditionally prepared during rituals and ceremonies in the northern regions of the Philippines. Its fermentation by-product, the Tapuy lees, is nutrient-dense but is underutilized for human consumption.
Junelle Rey C. Bacong, Mark Joseph R. Remucal, Paul Mark B. Medina   +2 more
doaj   +1 more source