Results 51 to 60 of about 27,951,681 (317)

Molecular pathways of major depressive disorder converge on the synapse

Molecular Psychiatry, 2022
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood molecular etiology. Extensive studies at different molecular levels point to a high complexity of numerous interrelated pathways as the underpinnings of depression. Major
G. Fries, Valeria A Saldana, Johannes Finnstein, T. Rein   +3 more
semanticscholar   +1 more source

Turbulent Driving Scales in Molecular Clouds

, 2009
Supersonic turbulence in molecular clouds is a dominant agent that strongly affects the clouds' evolution and star formation activity. Turbulence may be initiated and maintained by a number of processes, acting at a wide range of physical scales.
Anathpindika, Ballesteros-Paredes, Ballesteros-Paredes, Bally, Banerjee, Basu, Bergin, Brunt, Brunt, Brunt, Brunt, Brunt, C. M. Brunt, Dale, Dobbs, Elmegreen, Elmegreen, Falgarone, Glover, Goldsmith, Hartmann, Heitsch, Heyer, Heyer, Heyer, Heyer, Kim, Klessen, Knee, Koda, Larson, Lazarian, Lazarian, M. H. Heyer, M.-M. Mac Low, Mac Low, Mac Low, Mac Low, Matzner, Miesch, Offner, Ossenkopf, Ostriker, Pan, Price, Quillen, Ridge, Ridge, Rosolowsky, Scalo, Schneider, Shu, Stone, Stone, Stone, Swift, Walawender   +56 more
core   +1 more source

Galaxy chemical evolution models: The role of molecular gas formation [PDF]

, 2017
In our classical grid of multiphase chemical evolution models, star formation in the disc occurs in two steps: first, molecular gas forms, and then stars are created by cloud-cloud collisions or interactions of massive stars with the surrounding ...
Ascasibar, Yago, Díaz, Angeles I., Díaz, Ángeles I., Gibson, Brad K., Mollá, Mercedes   +4 more
core   +2 more sources

Tapuy lees attenuate amyloid-β toxicity and dopaminergic neurodegeneration more effectively than Tapuy wine in C. elegans models of Alzheimer’s and Parkinson’s disease

Discover Food
Tapuy is a traditional rice wine from the Philippines. We explored the potential of Tapuy wine and its fermentation by-product, lees, in reducing amyloid-beta toxicity in Alzheimer’s disease (AD) and dopaminergic neurodegeneration in Parkinson’s disease (
Mark Joseph R. Remucal, Junelle Rey C. Bacong, Paul Mark B. Medina   +2 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Ultrasensitive gene regulation by positive feedback loops in nucleosome modification

Molecular Systems Biology, 2008
Eukaryotic transcription involves the synergistic interaction of many different proteins. However, the question remains how eukaryotic promoters achieve ultrasensitive or threshold responses to changes in the concentration or activity of a single ...
Kim Sneppen, Mille A Micheelsen, Ian B Dodd   +2 more
doaj   +1 more source

Quaternions in molecular modeling [PDF]

Journal of Molecular Graphics and Modelling, 2007
Quaternions are an important tool to describe the orientation of a molecule. This paper considers the use of quaternions in matching two conformations of a molecule, in interpolating rotations, in performing statistics on orientational data, in the random sampling of rotations, and in establishing grids in orientation space.
openaire   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axis

Molecular Medicine, 2020
Background Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis.
Xuan Li, Zi-Zheng Zou, Min Wen, Yuan-Zhu Xie, Kun-Jian Peng, Tiao Luo, Su-You Liu, Qin Gu, Ji-Jia Li, Zhi-Yong Luo   +9 more
doaj   +1 more source

LIME - a flexible, non-LTE line excitation and radiation transfer method for millimeter and far-infrared wavelengths [PDF]

, 2010
We present a new code for solving the molecular and atomic excitation and radiation transfer problem in a molecular gas and predicting emergent spectra.
Bordag, Michael, Lambiase, G., Nesterenko, V.V.   +2 more
core   +1 more source