Results 81 to 90 of about 27,388,041 (218)

Markov Models of Molecular Kinetics [PDF]

The Journal of Chemical Physics, 2013
The Journal of Chemical Physics (JCP) article collection on Markov Models of Molecular Kinetics (MMMK) features recent advances developing and using Markov State Models (MSMs) in atomistic molecular simulations and related applications. This editorial provides a brief overview of the state of the art in the field and relates it to the articles in this ...
Frank Noé, Edina Rosta
openaire   +6 more sources

A Molecular-Mechanical Model of the Microtubule [PDF]

Biophysical Journal, 2005
Dynamic instability of MTs is thought to be regulated by biochemical transformations within tubulin dimers that are coupled to the hydrolysis of bound GTP. Structural studies of nucleotide-bound tubulin dimers have recently provided a concrete basis for understanding how these transformations may contribute to MT dynamic instability.
Elena A. Ermakova, Fazly I. Ataullakhanov, J. Richard McIntosh, Ekaterina L. Grishchuk, Maxim I. Molodtsov, Emmanuil E. Shnol   +5 more
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The Cordyceps Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach

Pharmaceuticals
Background/Objectives: Cancer remains one of the leading causes of mortality globally, underscoring the need for novel therapeutic strategies capable of targeting multiple molecular pathways simultaneously.
Jose Luis Gonzalez-Llerena, Daniela Treviño-Almaguer, Jesus Alejandro Leal-Mendez, Gael Garcia-Valdez, Arely Guadalupe Balderas-Moreno, Michel Stéphane Heya, Isaias Balderas-Renteria, María del Rayo Camacho-Corona, Bryan Alejandro Espinosa-Rodriguez   +8 more
doaj   +1 more source

Antimicrobial Peptides as Anticancer Agents: Functional Properties and Biological Activities

Molecules, 2020
Antimicrobial peptides (AMPs), or host defense peptides, are small cationic or amphipathic molecules produced by prokaryotic and eukaryotic organisms that play a key role in the innate immune defense against viruses, bacteria and fungi.
Anna Lucia Tornesello, Antonella Borrelli, Luigi Buonaguro, Franco Maria Buonaguro, Maria Lina Tornesello   +4 more
doaj   +1 more source

On Atomistic Models for Molecular Oxygen

The Journal of Physical Chemistry B, 2017
Molecular oxygen (O2) is key to all life on earth, as it is constantly cycled via photosynthesis and cellular respiration. Substantial scientific effort has been devoted to understanding every part of this cycle. Classical molecular dynamics (MD) simulations have been used to study some of the key processes involved in cellular respiration: O2 ...
Ilpo Vattulainen, Ilpo Vattulainen, Ilpo Vattulainen, Luca Monticelli, Matti Javanainen   +4 more
openaire   +6 more sources

Severity parameter and global importance factor of non-newtonian models in 3D reconstructed human left coronary artery [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Chatzizisis, YS, Giannoglou, GD, Seralidou, KV, Soulis, JV   +4 more
core  

Do we need to know the temperature in prestellar cores?

, 2007
Molecular line observations of starless (prestellar) cores combined with a chemical evolution modeling and radiative transfer calculations are a powerful tool to study the earliest stages of star formation. However, conclusions drawn from such a modeling
Henning, Th., Pavlyuchenkov, Ya., Wiebe, D.   +2 more
core   +1 more source

The effects of runs-of-homozygosity on pig domestication and breeding

BMC Genomics
Background Since their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs.
Lin Tao, Hang Liu, Adeniyi C. Adeola, Hai-Bing Xie, Shu-Tang Feng, Ya-Ping Zhang   +5 more
doaj   +1 more source

Epithelial–mesenchymal transition (EMT) and its role in acquired epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) chemoresistance in non-small cell lung cancer (NSCLC)

Cancer Pathogenesis and Therapy
Epithelial–mesenchymal transition (EMT) is a biological process that involves the transformation of epithelial cells into cells with a mesenchymal phenotype, enhancing their migratory and invasive capabilities.
Ma. Carmela P. Dela Cruz, Paul Mark B. Medina   +1 more
doaj   +1 more source

Phenolic-rich lees from Philippine rice wine (tapuy) increases Caenorhabditis elegans lifespan in spite of having low antioxidant activity

Food Production, Processing and Nutrition
Tapuy is an indigenous wine produced in the Philippines. Rice wine fermentation produces a by-product of rice leftover and microbial biomass, collectively called lees, which usually is discarded as a waste product.
Sean Philippe L. Chua, Lesley Dale Umayat, Paul Mark B. Medina   +2 more
doaj   +1 more source