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Reflections of Practicing School Principals on Ethical Leadership and Decision-Making: Confronting Social Injustice [PDF]

, 2015
The study objective was to identify leadership dilemmas of practicing school administrators and their own codes of ethics to inform understandings of ethical decision-making. Ethical decision-making underpins leadership practice, theory, and preparation.
Gardiner, Mary E., Tenuto, Penny L.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Assessing the evolution of primary healthcare organizations and their performance (2005-2010) in two regions of Québec province: Montréal and Montérégie

BMC Family Practice, 2010
Background The Canadian healthcare system is currently experiencing important organizational transformations through the reform of primary healthcare (PHC).
Provost Sylvie, Pineault Raynald, Levesque Jean-Frédéric, Tousignant Pierre, Couture Audrey, Da Silva Roxane, Breton Mylaine   +6 more
doaj   +1 more source

Organizational learning: Where do we stand? Where do we want to go? [PDF]

The field of organizational learning has developed dynamically but is not ready for closure. This article reviews the cultural contexts in which research on organizational learning has been conducted since the 1960s, and the intellectual traditions that ...
Antal, Ariane Berthoin, Dierkes, Meinolf
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Moving from product-oriented to platform-oriented business mod

Boletín de Estudios Económicos
Many product manufacturers are transitioning into platform providers, a shift that requires a series of organizational changes. Nevertheless, limited attention has been given to the motivations behind this shift and the specific organizational changes ...
Guilherme Sales Smania, Glauco Henrique de Sousa Mendes   +1 more
doaj   +1 more source

Generic Process Transformation Model: Transition to Process-based Organization [PDF]

The competitive global market climate of the new millennium has raised awareness of business processes as the most important management paradigm (Levi, 2002).
Tomislav Hernaus
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Mapping Activity Theory Diagrams into i* Organizational Models

Journal of Computer Science and Technology, 2005
Modern requirement engineering approaches divide the elicitation process in two different stages: one focused on analyzing the context where the system-to-be will be used and another centered on designing software solutions appropriated to the context ...
Genésio Gomes da Cruz Neto, Alex Sandro Gomes, Jaelson Brelaz de Castro   +2 more
doaj  

Impact of Servitized Corporate Models in Providing A Competitive Edge to The Manufacturing Industry

JTRM
This document reviews the impact of servitization on manufacturing companies' corporate models. It discusses how product-centric firms can transition to service-oriented models by incorporating software services into their offerings.
S M Nazmuz Sakib
doaj   +1 more source