Results 71 to 80 of about 128,362 (267)

Assessing the evolution of primary healthcare organizations and their performance (2005-2010) in two regions of Québec province: Montréal and Montérégie

BMC Family Practice, 2010
Background The Canadian healthcare system is currently experiencing important organizational transformations through the reform of primary healthcare (PHC).
Provost Sylvie, Pineault Raynald, Levesque Jean-Frédéric, Tousignant Pierre, Couture Audrey, Da Silva Roxane, Breton Mylaine   +6 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Moving from product-oriented to platform-oriented business mod

Boletín de Estudios Económicos
Many product manufacturers are transitioning into platform providers, a shift that requires a series of organizational changes. Nevertheless, limited attention has been given to the motivations behind this shift and the specific organizational changes ...
Guilherme Sales Smania, Glauco Henrique de Sousa Mendes   +1 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Mapping Activity Theory Diagrams into i* Organizational Models

Journal of Computer Science and Technology, 2005
Modern requirement engineering approaches divide the elicitation process in two different stages: one focused on analyzing the context where the system-to-be will be used and another centered on designing software solutions appropriated to the context ...
Genésio Gomes da Cruz Neto, Alex Sandro Gomes, Jaelson Brelaz de Castro   +2 more
doaj  

Impact of Servitized Corporate Models in Providing A Competitive Edge to The Manufacturing Industry

JTRM
This document reviews the impact of servitization on manufacturing companies' corporate models. It discusses how product-centric firms can transition to service-oriented models by incorporating software services into their offerings.
S M Nazmuz Sakib
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Modelos de gestão flexíveis a partir de mudanças na cultura organizacional alicerçada no empreendedorismo

Revista de Ciências da Administração : RCA, 2003
The search for survival before world-wide market, allied to the influence of new technologies, has obliged managers to promote changes in the organizational culture.
Fabiano Maury Raupp, Ilse Maria Beuren
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source