Results 101 to 110 of about 2,283,718 (199)

QInfoMating: sexual selection and assortative mating estimation software. [PDF]

BMC Ecol Evol
Carvajal-Rodríguez A.
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Using the Coefficient of Conformism of a Correlative Prediction in Simulation of Cardiotoxicity. [PDF]

Toxics
Toropova AP, Toropov AA, Roncaglioni A, Benfenati E.   +3 more
europepmc   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Assessing dengue forecasting methods: a comparative study of statistical models and machine learning techniques in Rio de Janeiro, Brazil. [PDF]

Trop Med Health
Chen X, Moraga P.
europepmc   +1 more source

Modeling natural microimage statistics

, 2000
A large collection of digital images of natural scenes provides a database for analyzing and modeling small scene patches (e.g., 2 x 2) referred to as natural microimages. A pivotal ¯nding is the stability of the empirical microimage distribution across scene samples and with respect to scaling. With a view toward potential applications (e.g.
openaire   +9 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Development of an integrated reactor model package for optimizing the operating modes of the sulfur production unit. [PDF]

Sci Rep
Orazbayev B, Kurbangaliyeva N, Orazbayeva K, Zhumadillayeva A, Yue X.   +4 more
europepmc   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Predictive hybrid model of a grid-connected photovoltaic system with DC-DC converters under extreme altitude conditions at 3800 meters above sea level. [PDF]

PLoS One
Cruz J, Baca L, Beltran N, Chura J, Calsina H, Sarmiento V, Condori R, Huaquipaco S, Yana-Mamani V, Macêdo WN, Mamani W.   +10 more
europepmc   +1 more source