Results 71 to 80 of about 32,339,977 (323)
Fisetin may protect early porcine embryos from oxidative stress by down-regulating GRP78 levels [PDF]
PeerJFisetin is a natural flavonol with a variety of biological activities, including anti-inflammatory and antitumor activities. However, the effect of fisetin on mammalian oocyte and embryo development is unknown, so in this study, we used porcine oocytes ...
Xiu-Wen Yuan +9 more
doaj +2 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Ecological Questions, 2008 When searching for nature rules we encounter a fundamental difficulty: for technical reasons we are not able to investigate the whole Nature - we have to explore its sections i.e. empirical systems (structures). However, even then it might happen that the system is too complex and its comprehensive, direct investigation is impossible.
openaire +3 more sources
Nested Models and Model Uncertainty [PDF]
The Scandinavian Journal of Economics, 2015 AbstractUncertainty about the appropriate choice among nested models is a concern for optimal policy when policy prescriptions from those models differ. The standard procedure is to specify a prior over the parameter space, ignoring the special status of submodels (e.g., those resulting from zero restrictions).
Kriwoluzky, A., Stoltenberg, C.A.
openaire +8 more sources
VacciMonitor, 2009 mmunization is one of the most successful and cost-effective health interventions ever. Immunization have been helping to reduce child mortality, improving maternal health and combating infectious diseases.
González E +12 more
doaj
Quo natas, Danio?—Recent Progress in Modeling Cancer in Zebrafish
Frontiers in Oncology, 2017 Over the last decade, zebrafish has proven to be a powerful model in cancer research. Zebrafish form tumors that histologically and genetically resemble human cancers.
Stefanie Kirchberger +3 more
doaj +1 more source
SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Journal of Experimental & Clinical Cancer Research, 2021 Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy.
Elisabetta Valentini +3 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Scientific ReportsLiver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells (ECs) that play an important role in liver development and regeneration. Additionally, it is involved in various pathological processes, including steatosis, inflammation,
Shang-Ping Tian +7 more
doaj +1 more source