Results 101 to 110 of about 137,955 (315)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Multicomponent dark matter with collider implications

Journal of High Energy Physics
The present work aims to study an extension of the Standard Model (SM) that addresses the prominent SM shortcomings, i.e., can explain the neutrino mass, the dark matter (DM) content, and the matter-antimatter asymmetry of the Universe.
Laura Covi, Shyamashish Dey, Sarif Khan, Santosh Kumar Rai   +3 more
doaj   +1 more source

Sculpting Andromeda – made-to-measure models for M31’s bar and composite bulge: dynamics, stellar and dark matter mass [PDF]

, 2018
M. Blaña, Ortwin Gerhard, Christopher Wegg, Matthieu Portail, M. Opitsch, R. P. Saglia, Maximilian Fabricius, Peter Erwin, R. Bender   +8 more
openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Comment on “Modeling galaxy halos using dark matter with pressure” [PDF]

, 2009
Kung-Yi Su, Pisin Chen
openalex   +1 more source

Fitting a self-interacting dark matter model to data ranging from satellite galaxies to galaxy clusters [PDF]

, 2023
Sudhakantha Girmohanta, Robert Shrock
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

SLIM at LHC: LHC search power for a model linking dark matter and neutrino mass [PDF]

, 2010
Y. Farzan, M. Hashemi
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Measurement of Milli-Charged particles with a moderately large cross section from the Earth’s core at IceCube

Journal of High Energy Physics
It is assumed that heavy dark matter ϕ with O(TeV) mass captured by the Earth may decay to relativistic light milli-charged particles (MCPs). These MCPs could be measured by the IceCube neutrino telescope.
Ye Xu
doaj   +1 more source