Results 101 to 110 of about 902,528 (341)

Light in the shadows: primordial black holes making dark matter shine

Journal of High Energy Physics
We consider the possibility of indirect detection of dark sector processes by investigating a novel form of interaction between ambient dark matter (DM) and primordial black holes (PBHs). The basic scenario we envisage is that the ambient DM is “dormant”,
Kaustubh Agashe, Manuel A. Buen-Abad, Jae Hyeok Chang, Steven J. Clark, Bhaskar Dutta, Yuhsin Tsai, Tao Xu   +6 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Enhancement of p-wave dark matter annihilation by quasi-bound states

Journal of High Energy Physics
We scrutinize the Sommerfeld enhancement in dark matter pair annihilation for p-wave and higher-ℓ partial waves. For the Yukawa potential these feature a super-resonant Breit-Wigner peak in their velocity-dependence close to Sommerfeld resonances as well
Martin Beneke, Tobias Binder, Lorenzo De Ros, Mathias Garny   +3 more
doaj   +1 more source

Constraints on the Coupling between Dark Energy and Dark Matter from CMB data

, 2016
We investigate a phenomenological non-gravitational coupling between dark energy and dark matter, where the interaction in the dark sector is parameterized as an energy transfer either from dark matter to dark energy or the opposite.
Fornengo, Nicolao, Gariazzo, Stefano, Murgia, Riccardo   +2 more
core   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

The quintuplet annihilation spectrum

Journal of High Energy Physics
We extend the Effective Field Theory of Heavy Dark Matter to arbitrary odd representations of SU(2) and incorporate the effects of bound states. This formalism is then deployed to compute the gamma-ray spectrum for a 5 of SU(2): quintuplet dark matter ...
Matthew Baumgart, Nicholas L. Rodd, Tracy R. Slatyer, Varun Vaidya   +3 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Newtonian Approach to the Matter Power Spectrum of the Generalized Chaplygin Gas

, 2008
We model the cosmic medium as the mixture of a generalized Chaplygin gas and a pressureless matter component. Within a neo-Newtonian approach we compute the matter power spectrum.
Bardeen, Bento, Beça, Borges, Cole, Colistete, Colistete, Fabris, Gorini, H.E.S. Velten, Harrison, J.C. Fabris, Kamenshchik, Lima, McCrea, Reis, S.V.B. Goncalves, Sandvik, W. Zimdahl   +18 more
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Revisiting the decoupling limit of the Georgi-Machacek model with a scalar singlet

Journal of High Energy Physics
We study the connection between collider and dark matter phenomenology in the singlet extension of the Georgi-Machacek model. In this framework, the singlet scalar serves as a suitable thermal dark matter (DM) candidate. Our focus lies on the region v χ <
Geneviève Bélanger, Juhi Dutta, Rohini M. Godbole, Sabine Kraml, Manimala Mitra, Rojalin Padhan, Abhishek Roy   +6 more
doaj   +1 more source