Results 61 to 70 of about 319,252 (292)

Moderate deviations-based importance sampling for stochastic recursive equations [PDF]

open access: yes, 2017
Subsolutions to the Hamilton–Jacobi–Bellman equation associated with a moderate deviations approximation are used to design importance sampling changes of measure for stochastic recursive equations.
Dane Johnson, Paul Dupuis
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Density, viscosity and refractive index of the dimethyl sulfoxide + o-xylene system [PDF]

open access: yesJournal of the Serbian Chemical Society, 2009
This work reports the experimental results of the densities, viscosities and refractive indices between 298.15 and 323.15 K of the dimethyl sulfoxide + o-xylene system over the entire composition range of the mixtures.
OANA CIOCIRLAN, OLGA IULIAN
doaj   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Pointwise Sharp Moderate Deviations for a Kernel Density Estimator

open access: yesMathematics
Let fn be the non-parametric kernel density estimator based on a kernel function K and a sequence of independent and identically distributed random vectors taking values in Rd.
Siyu Liu   +3 more
doaj   +1 more source

Large Deviations in Testing Squared Radial Ornstein-Uhleneck Model

open access: yesJournal of Probability and Statistics, 2011
We study the large deviations and moderate deviations of hypothesis testing for squared radial Ornstein-Uhleneck model. Large deviation principles for the log-likelihood ratio are obtained, by which we give negative regions in testing squared radial ...
Shoujiang Zhao, Qiaojing Liu
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Moderate deviations on Poisson chaos

open access: yesElectronic Journal of Probability
This paper deals with U-statistics of Poisson processes and multiple Wiener-Itô integrals on the Poisson space. Via sharp bounds on the cumulants for both classes of random variables, moderate deviation principles, concentration inequalities and normal approximation bounds with Cramér correction are derived.
Schulte, Matthias, Thäle, Christoph
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Linking interview speed and interviewer effects on target variables in face-to-face surveys

open access: yesSurvey Research Methods, 2019
Research has explained interviewer effects in face-to-face surveys: in terms of question, respondent and interviewer characteristics. In this paper, we relate interview speed to interviewer effects.
Caroline Vandenplas   +2 more
doaj   +1 more source

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